Results 191 to 200 of about 281,052 (341)

Recall Reaction of a Severe Local Peripheral Neuropathy After Paclitaxel Extravasation [PDF]

, 1996
Manuel Hidalgo, Jordi Moreno Benito, Rámón Colomer, Luis Paz‐Ares   +3 more
openalex   +1 more source

Cationic Nanoparticles Mitigate Chemotherapy‐Induced Peripheral Neuropathy

Advanced NanoBiomed Research, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN), caused by chemodrugs like paclitaxel (PTX), leads to severe neuropathic pain. This study evaluates PTX‐loaded PAMAM‐Chol nanoparticles (PTX‐NPs) to alleviate CIPN. PTX‐NPs achieve 99% drug‐loading efficiency, reduce neurotoxicity, and in murine models, decrease cold allodynia by 85% while restoring ...
Divya Bhansali, Rocco Latorre, Raquel Tonello, David Poolman, Suwan Ding, Brian L. Schmidt, Nigel W. Bunnett, Kam W. Leong   +7 more
wiley   +1 more source

Advances on Albumin‐Based Carriers for Anticancer Drug Delivery

Advanced NanoBiomed Research, EarlyView.
This study systematically classifies the drug delivery modes of albumin by examining the characteristics of its surface‐active groups and internal binding sites. It provides an in‐depth analysis of various drug delivery strategies and their corresponding targeting mechanisms.
Ruoli Zhou, Rongbin Zhong, Zhonghui Luo, Hua Wei, Cui‐Yun Yu   +4 more
wiley   +1 more source

Phase I trial of paclitaxel and gemcitabine administered every two weeks in patients with refractory solid tumors

, 1998
Mace L. Rothenberg, A. Sharma, Geoffrey R. Weiss, Miguel A. Villalona‐Calero, John R. Eckardt, C. Aylesworth, Maura A. Kraynak, David Rinaldi, Gladys Rodriguez, H. A. Burris, S. Gail Eckhardt, Connie Stephens, Kelly Forral, Steven J. Nicol, Daniel D. Von Hoff   +14 more
openalex   +1 more source

Engineered Hydrogels Revolutionize Locoregional Cancer Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review systematically summarizes the latest research progress on injectable hydrogels in cancer immunotherapy, highlighting their unique advantages in precise immune activation, local drug‐controlled release, and immune microenvironment remodeling. These features provide innovative solutions to overcome the bottlenecks of systemic side effects and
Jiyong Wei, Chunliu Huang, Zenghua Zhou, Yanni Lan   +3 more
wiley   +1 more source

Single-nucleus rna sequencing identifies universal camk1d upregulation and dysregulated c-ltmr subtypes as key drivers of paclitaxel-induced neuropathy. [PDF]

Cell Biol Toxicol
Sun W, Li R, Zhang X, Wu S, Jiang Y, Li Q, Cao D, Xiong D, Xiao L, Liu X.   +9 more
europepmc   +1 more source

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

Phosphorylated IRF3 promotes GSDME-mediated pyroptosis through RIPK1/FADD/caspase-8 complex formation during mitotic arrest in ovarian cancer. [PDF]

Cell Commun Signal
Gong W, Zhou D, Xu Q, Wang L, Luo M, Zhang Y, Liao Z, Xiong F, Zhao G, Zhao B, Gao Q, Fang Y.   +11 more
europepmc   +1 more source

Paclitaxel (Taxol) and Docetaxel (Taxotere): active chemotherapeutic agents in lung cancer

, 1995
Prudence A. Francis, Mark G. Kris, James R. Rigas, Stefan C. Grant, Vincent A. Miller   +4 more
openalex   +1 more source

Emerging Strategies for Platelet‐Modified Nanoparticles in Targeted Tumor Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights innovative strategies using platelet‐modified nanoparticles to target tumors more precisely. By mimicking platelet functions, these biomimetic carriers improve tumor homing, enhance drug delivery, and reduce immune clearance.
Chunyu Bai, Lan Sun, Yimin Cui, Huan Meng, Jiulong Li, Qian Xiang   +5 more
wiley   +1 more source