Results 201 to 210 of about 213,637 (257)

Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application

Responsive Materials, EarlyView.
Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li, Xue Wu, Zekun Yan, Jun Wu, Caishi Huang, Songnan Qu   +5 more
wiley   +1 more source

Paclitaxel oral solution versus paclitaxel injection as second-line therapy for advanced gastric cancer: a multicenter, open-label, randomized phase III trial. [PDF]

ESMO Open
Li J, Huang M, Deng T, Bai Y, Liu T, Pan Y, Yu J, Pan H, Xu H, Wang J, Ye F, Wang J, Wu J, Cang S, Chen K, Zhang J, Zhang J, Ling Y, Zhong H, Fu G, Liu H, Huang L, Pan Y, Zhang L, Liu L, Ye X, Wu M, Zheng Z, Huang J, Liang X, Liu Y, Ding Y, Bai C, Yang L, Yan P, Miao J, Lu H, Bi Q, Zhou Y, Peng Y, Lin H, Deng Y, Zhong D, Gao C, Liu H, Tan S, Yi T, Liu Y, Song L, Chen Y, Qin S.   +50 more
europepmc   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

Risk prediction of severe chemotherapy-induced peripheral neuropathy in breast cancer patients receiving nab-paclitaxel: a clinical nomogram. [PDF]

Front Pharmacol
Tong Y, Liang T, Yu J, Ning H, Zhang X, Zhang Z, Liu S, Yang M.   +7 more
europepmc   +1 more source

Cell‐Based Micro/Nanorobots: From Living Carriers to Living Therapeutic Specialists

SmartBot, EarlyView.
Cell‐based micro/nanorobots integrate evolutionarily acquired biological intelligence with engineered capabilities, offering new opportunities for precision medicine in vivo. However, the complex physiological environments of different organs pose significant challenges to their clinical translation.
Junfeng Wu, Zhaoyu Zhang, Ke Xu, Enkuo Li, Yuting Cui, Yuting Zhou, Huanyu Zhou, Beipei Zhang, Shuai Jiang, Xiaodong Wang, Jialin Jiang, Lianqing Liu, Niandong Jiao   +12 more
wiley   +1 more source

PDA‐Engineered 3D‐Printed Polymer–ZrO2 Hybrid Scaffolds Enabling Enhanced Radiopacity, Photothermal Therapy, and Cell Migration Modulation

Small, EarlyView.
A multifunctional 3D‐printed polymer–ZrO2 scaffold is developed to provide intrinsic radiopacity, photothermal responsiveness, and surface bioactivity. Reinforcement with ZrO2 enables real‐time x‐ray visibility and mechanical robustness, while a polydopamine coating facilitates near‐infrared‐triggered drug release and modulates cell migration, thereby ...
Sumin Kang, Yun‐Jin Jeong, Seokjae Kim, Van Du Nguyen, Songah Jeong, Juyeong Jo, Arunkumar Shanmugasundaram, Jin Uk Jeong, Dong‐Weon Lee, Eunpyo Choi, Hyungwoo Kim   +10 more
wiley   +1 more source

Matching-adjusted indirect comparison of fruquintinib versus ramucirumab in advanced gastric or gastroesophageal junction adenocarcinoma. [PDF]

J Comp Eff Res
An N, Chen J, Li J, Shen L, Guo W, Liu T, Li J, Qin S, Bai Y, Chen Z, Wang J, Pan Y, Xu R, Wang F.   +13 more
europepmc   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source