Results 191 to 200 of about 213,637 (257)

Molecular Mechanisms and Signaling Pathways Underlying the Synergistic Effect of Metformin and Paclitaxel in Preclinical Cancer Models: A Systematic Review. [PDF]

Cancer Manag Res
Omidi Sarajar B, Khederzadeh A, Payoon A, Zarei MH, Jafarzadeh E.   +4 more
europepmc   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Integrated Computational Modeling Reveals a Structurally Plausible Transient Paclitaxel-NK2R Interaction. [PDF]

Bioengineering (Basel)
Duda-Seiman C, Tartau LM, Hoinoiu B, Pit D, Dumitrascu V, Tanase AD, Rusu E, Luca A, Popa EG, Hoinoiu T.   +9 more
europepmc   +1 more source

Plant‐Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy

Phytotherapy Research, EarlyView.
This illustration shows the biogenesis pathways of edible and medicinal plant‐derived extracellular vesicles (PDEVs) and their therapeutic effects following uptake in the human body, highlighting their potential for application in cancer immunotherapy. ABSTRACT Plant‐derived extracellular vesicles (PDEVs) are nanoscale, lipid bilayer‐enclosed vesicles ...
Guosheng Li, Mengyu Li, Shujing Liu, Yuan Wei, Chen Wang   +4 more
wiley   +1 more source

Honokiol Suppresses Stemness and Sensitizes Triple-Negative Breast Cancer to Chemotherapy via YAP/TAZ-TEAD Inhibition. [PDF]

Oncol Res
Xia JN, Zhu SD, Qu WL, Hu YL, Ma WY, Wang W, Huang QL, Lin BY, Guo JE, Li YW.   +9 more
europepmc   +1 more source

Dihydrotanshinone I Targets MIF to Inhibit GSK‐3β/β‐Catenin Axis‐Mediated Invasion and Metastasis in Gastric Cancer

Phytotherapy Research, EarlyView.
DHT directly binds to MIF and subsequently blunts AKT signaling, which restores the kinase activity of GSK‐3β. The reactivated GSK‐3β then promotes the phosphorylation (Ser33/37/Thr41) and proteasomal degradation of β‐catenin, thereby preventing its nuclear translocation and inhibiting the transcription of EMT‐related genes (e.g., Snail and Twist ...
Chuhang Wang, Xiaochen Ni, Yuyan Pan, Wei Fan, Jianing Guo, Kaiyuan Zhang, Mingsi Zhang, Linfeng Zheng, Yunhai Wei, Tao Jiang, Guangji Zhang   +10 more
wiley   +1 more source

Docetaxel for recurrent adult granulosa cell tumor enabling tertiary cytoreduction. [PDF]

Gynecol Oncol Rep
Ali M, Chua KJC, Chen H.
europepmc   +1 more source

4′‐Hydroxywogonin Attenuates Hepatocellular Carcinoma Progression by Suppressing Gas6/Axl‐PI3K/AKT Signaling

Phytotherapy Research, EarlyView.
4′‐Hydroxywogonin, a flavonoid derived from Scutellaria baicalensis, inhibits hepatocellular carcinoma progression partly by suppressing Gas6/Axl‐PI3K/AKT signaling, inducing cell cycle arrest and apoptosis, and reducing metastatic potential. It also suppresses xenograft tumor growth without evident hepatotoxicity.
Chi‐Yuan Chen, Chin‐Chuan Chen, Chau‐Ting Yeh, Chieh‐Wen Chan, Yu‐De Chu, Yann‐Lii Leu, Roshan B. Satange, Li‐Fang Chou, Wen‐Yu Chuang, Chuen Hsueh, Tzong‐Ming Shieh, Tong‐Hong Wang   +11 more
wiley   +1 more source

Randomized phase II trial of zolbetuximab as second-line treatment in patients with claudin 18.2-positive advanced gastric/GEJ cancer with previous zolbetuximab exposure: ZELDA. [PDF]

ESMO Gastrointest Oncol
Inagaki C, Oki E, Ando K, Hirano H, Furuta M, Narita Y, Esaki T, Murotani K, Kawakami H, Muro K.   +9 more
europepmc   +1 more source