Results 31 to 40 of about 261,105 (346)

The effect of paclitaxel on apoptosis, autophagy and mitotic catastrophe in AGS cells

Scientific Reports, 2021
Paclitaxel is an anti-microtubule agent that has been shown to induce cell death in gastric cancer. However, the detailed mechanism of action is unclear.
Tin Myo Khing, Won Seok Choi, Dong Min Kim, W. Po, Wynn Thein, C. Shin, U. Sohn   +6 more
semanticscholar   +1 more source

Paclitaxel Increases High Voltage–Dependent Calcium Channel Current in Dorsal Root Ganglion Neurons of the Rat

Journal of Pharmacological Sciences, 2012
Peripheral neuropathic pain is a serious side effect of paclitaxel treatment. However, the mechanism of this paclitaxel-induced neuropathic pain is unknown. In this study, we investigated the effects of paclitaxel on the voltage-dependent calcium channel
Kazuyoshi Kawakami, Terumasa Chiba, Nobuyuki Katagiri, Maya Saduka, Kenji Abe, Iku Utsunomiya, Toshihiro Hama, Kyoji Taguchi   +7 more
doaj   +1 more source

A hybrid model based on general regression neural network and fruit fly optimization algorithm for forecasting and optimizing paclitaxel biosynthesis in Corylus avellana cell culture

Plant Methods, 2021
Background Paclitaxel is a well-known chemotherapeutic agent widely applied as a therapy for various types of cancers. In vitro culture of Corylus avellana has been named as a promising and low-cost strategy for paclitaxel production.
M. Salehi, S. Farhadi, A. Moieni, N. Safaie, M. Hesami   +4 more
semanticscholar   +1 more source

Effect of paclitaxel and resveratrol on New Zealand rabbit semen

Asian Pacific Journal of Reproduction, 2018
Objective: To examine the effects of paclitaxel and resveratrol on rabbit semen. Methods: This study consisted of four groups: control group (40 mL saline), paclitaxel group (5 mg/kg paclitaxel), resveratrol group (4 mg/kg resveratrol) and paclitaxel ...
Caner Ozturk, Mehmet Bozkurt Ataman
doaj   +1 more source

Progress in research on paclitaxel and tumor immunotherapy

Cellular & Molecular Biology Letters, 2019
Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is considered to be one of the most successful natural anticancer drugs available.
Linyan Zhu, Liqun Chen
semanticscholar   +1 more source

Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction

Tumor Biology, 2017
Non-small-cell lung cancer is one of the most lethal cancers in the worldwide. Although Paclitaxel-based combinational therapies have long been used as a standard treatment in aggressive non-small-cell lung cancers, Paclitaxel resistance emerges as a ...
Yimin Lu, Jun Wang, Lei Liu, Lequn Yu, Nian Zhao, Xingju Zhou, Xudong Lu   +6 more
doaj   +1 more source

Risk of Death Following Application of Paclitaxel‐Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2018
Background Several randomized controlled trials (RCTs) have already shown that paclitaxel‐coated balloons and stents significantly reduce the rates of vessel restenosis and target lesion revascularization after lower extremity interventions.
K. Katsanos, S. Spiliopoulos, P. Kitrou, M. Krokidis, D. Karnabatidis   +4 more
semanticscholar   +1 more source

Adverse event profiles of solvent-based and nanoparticle albumin-bound paclitaxel formulations using the Food and Drug Administration Adverse Event Reporting System

SAGE Open Medicine, 2019
Objectives: Paclitaxel is a highly effective antitumor agent with notable adverse events, including hypersensitivity reactions, peripheral neuropathy, arthralgia, myalgias, and neutropenia.
Misa Naganuma, Kohei Tahara, Shiori Hasegawa, Akiho Fukuda, Sayaka Sasaoka, Haruna Hatahira, Yumi Motooka, Satoshi Nakao, Ririka Mukai, Kouseki Hirade, Tomoaki Yoshimura, Takeshi Kato, Hirofumi Takeuchi, Mitsuhiro Nakamura   +13 more
doaj   +1 more source

Rikkunshito prevents paclitaxel-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice.

PLoS ONE, 2017
Peripheral neuropathy is the major side effect caused by paclitaxel, a microtubule-binding antineoplastic drug. Paclitaxel-induced peripheral neuropathy causes a long-term negative impact on the patient's quality of life.
Junzo Kamei, Shunsuke Hayashi, Akane Sakai, Yuki Nakanishi, Misa Kai, Megumi Ikegami, Hiroko Ikeda   +6 more
doaj   +1 more source

Chemopreventive effects of Xiang Sha Liu Jun Zi Tang on paclitaxel-induced leucopenia and neuropathy in animals

Frontiers in Pharmacology, 2023
Paclitaxel frequently induces peripheral neuropathy and myelosuppression during cancer treatment. According to the National Health Insurance Research Database of Taiwan, traditional Chinese medicine doctors widely use Xiang Sha Liu Jun Zi Tang (XSLJZT ...
Her-Shyong Shiah, Her-Shyong Shiah, Her-Shyong Shiah, Chia-Jung Lee, Chia-Jung Lee, Chia-Jung Lee, Fang-Yu Lee, Sung-Hui Tseng, Sung-Hui Tseng, Shih-Han Chen, Ching-Chiung Wang, Ching-Chiung Wang, Ching-Chiung Wang, Ching-Chiung Wang   +13 more
doaj   +1 more source