Results 151 to 160 of about 2,661 (192)

Paeonol Nanoemulsion for Enhanced Oral Bioavailability: Optimization and Mechanism

open access: yesNanomedicine, 2018
Aim: The aim of this work was to optimize a nanoemulsion formulation and explain its absorption mechanism in improving the oral bioavailability of paeonol.
Min Dai
exaly   +2 more sources
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Study on the pharmacokinetics and metabolism of paeonol in rats treated with pure paeonol and an herbal preparation containing paeonol by using HPLC–DAD-MS method

Journal of Pharmaceutical and Biomedical Analysis, 2008
Paeonol, a principal bioactive component of the Chinese herb Moutan Cortex with anti-inflammatory and analgesic effects, was comparatively studied to determine its pharmacokinetic behavior and metabolic profile in rat following oral administration of the pure paeonol alone and an herbal preparation "Qingfu Guanjieshu" (QFGJS) containing paeonol.
Hua Zhou, Zhi-Hong Jiang, Ying Xie
exaly   +3 more sources

Effects of Paeonol and Gastroretention Tablets of Paeonol on Experimental Gastric Ulcers and Intestinal Flora in Rats

Inflammation, 2020
Paeonol, a major ingredient isolated from Moutan Cort, has various pharmacological effects. Our previous studies have shown that paeonol can exert antioxidant and anti-inflammatory therapeutic effects on ethanol-induced experimental gastric ulcer (GU).
Zhicheng Wang, Bing Wang, Tong Zhang
exaly   +3 more sources

Paeonol: pharmacological effects and mechanisms of action

International Immunopharmacology, 2019
Paeonia suffruticosa possesses various medicinal benefits and has been used extensively in traditional oriental medicine for thousands of years. Paeonol is the main component isolated from the root bark of Paeonia suffruticosa. The pharmacological effects of Paeonia suffruticosa are mostly attributed to paeonol.
Li-Fang Liu
exaly   +3 more sources

Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway

open access: yesInternational Journal of Molecular Sciences, 2014
Chondrosarcoma, a primary malignant bone cancer, has potential for local invasion and distant metastasis, especially to the lungs. Patients diagnosed with it show poor prognosis. Paeonol (2\u27-hydroxy-4\u27-methoxyacetophenone), the main active compound
Jui-Chieh Chen   +2 more
exaly   +2 more sources

Synthesis and evaluation of acetylferulic paeonol ester and ferulic paeonol ester as potential antioxidants to inhibit fish oil oxidation

Food Chemistry, 2021
Acetylferulic paeonol ester (APE) and ferulic paeonol ester (FPE) were synthesized, and their structures were confirmed by NMR, mass spectra, IR and UV-vis data. The antioxidant properties of the synthesized compounds were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and [(2-azino-bis (3-ethylbenzthiazoline)-6 -sulfonic acid] (ABTS) assay as ...
Hua Wen, Juan Tian, Fan Wu
exaly   +3 more sources

Metabolism of Paeonol in Rats

Journal of Natural Products, 1999
As a part of our studies on the metabolism of active components from traditional Chinese medicines, paeonol was orally administered to rats. The urinary metabolites were analyzed by 3D HPLC, and their structures were determined to be 2, 4-dihydroxyacetophenone-5-O-sulfate (P1), resacetophenone-2-O-sulfate (P2), 2-hydroxy-4-methoxyacetophenone-5-O ...
T, Yasuda   +3 more
openaire   +2 more sources

Diuretic Action of Paeonol

Planta Medica, 1985
Effects of paeonol, a major component of the root bark of PAEONIA SUFFRUTICOSA, on urinary excretion of water (UV), sodium (U Na V), potassium (U K V), chloride (U cl V) and osmolality (U osm V) were investigated in bicarbonate saline loaded rats. Paeonol at the doses of 62.5 to 250 mg/kg p.o. produced dose-dependent increases in UV, U Na V and U
K, Kawashima   +5 more
openaire   +2 more sources

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