Results 161 to 170 of about 2,661 (192)

Vascular dilation by paeonol — A mechanism study

Vascular Pharmacology, 2010
The goal of this study was to investigate the mechanism underlaying the vasodilatory effect of paeonol, a major active element from the root bark of Chinese herbs Paeonia suffruticosa Andr. and Cynanchum paniculatum (Bunge) Kitagawa. Paeonol relaxed isolated rat aorta rings by 95.6% while the 10(-6) M forskolin-induced vasodilatation used as 100%.
Ya-juan, Li, Jun-Xiang, Bao, Jin-wen, Xu, Ferid, Murad, Ka, Bian   +4 more
openaire   +2 more sources

The interaction of paeonol with DPPC liposomes

Journal of Thermal Analysis and Calorimetry, 2017
Differential scanning calorimetry and synchrotron X-ray diffraction techniques have been employed to investigate the interaction of paeonol with DPPC liposomes and to investigate the location of paeonol molecules in liposomes. The results showed that the location of the paeonol molecules in liposomes is concentration dependent.
Geng Deng, Hai-Yuan Sun
exaly   +2 more sources

Anxiolytic-like effect of paeonol in mice

Pharmacology Biochemistry and Behavior, 2005
The present study in mice compared the putative anxiolytic-like effect of paeonol, a phenolic component from the root bark of Paeonia moutan, with the benzodiazepine diazepam in the elevated plus maze and the light/dark box-test. The comparison was also with regard to locomotor activity (open-field test) and myorelaxant potential (inclined plane test).
Xiao Juan, Mi, Si Wei, Chen, Wen Juan, Wang, Rui, Wang, Yi Jing, Zhang, Wei Jing, Li, Yu Lei, Li   +6 more
openaire   +2 more sources

Paeonol Derivatives and Pharmacological Activities: A Review of Recent Progress

Mini-Reviews in Medicinal Chemistry, 2020
Paeonol, 2-hydroxy-4-methoxy acetophenone, is one of the main active ingredients of traditional Chinese medicine such as Cynanchum paniculatum, Paeonia suffruticosa Andr and Paeonia lactiflora Pall. Modern medical research has shown that paeonol has a wide range of pharmacological activities. In recent years, a large number of studies have been carried
Haiping Chu, Guiying Wu, Jingyong Sun
exaly   +3 more sources

Protective mechanism of Paeonol on central nervous system

Phytotherapy Research, 2023
AbstractCerebrovascular diseases involve neuronal damage, resulting in degenerative neuropathy and posing a serious threat to human health. The discovery of effective drug components from natural plants and the study of their mechanism are a research idea different from chemical synthetic medicines.
Rui Wu, Yanfang Liu, Fang Zhang, Shu Dai, Xinyan Xue, Cheng Peng, Yan Li, Yunxia Li   +7 more
openaire   +2 more sources

Paeonol pharmacokinetics in the rat following i.m. administration

European Journal of Drug Metabolism and Pharmacokinetics, 2008
The pharmacokinetic behavior and bioavailability of paeonol were determined after a single intramuscular (i.m.) injection of 10 mg/kg to rats. Plasma paeonol concentrations were measured by high performance liquid chromatography (HPLC). The main pharmacokinetic parameters were as follows: mean elimination half-life (t(1/2z)) 59.85 +/- 10.23 min, time ...
Li-Yan, Ma, Xu-Dong, Xu, Qi, Zhang, Jian-Hua, Miao, Bing-Lan, Tang   +4 more
openaire   +2 more sources

Pharmacology Research Progress of Paeonol

Key Engineering Materials, 2014
Paeonol is one of main medicinal ingredients of Cortex Moutan. Paeonol has the functions of sedative, hypnosis, anti-bacterial, antibiosis, anti-inflammation, antioxidation, reducing blood pressure and so on. Paeonol has extensive biological activities and has broad prospects of exploitation and utilization.
Qi Guo, Chuan Xiang Zhao, Shi Qing Zhang, Zhao Ju, Fang Chen, Xin Tian, Ao Ran Yang, Ping Wang, Li Fang, Jie Guo, Zhi Guo Wang, Hua Xi Xu   +11 more
openaire   +1 more source

Pharmacokinetics of Paeonol after Intravenous Administration in Rats

Journal of Pharmaceutical Sciences, 1994
A simple high-performance liquid chromatography methodology was developed to study the pharmacokinetics of paeonol in the rat after intravenous (iv) bolus administration of various doses (2.5, 5, or 10 mg/kg). The pharmacokinetics of paeonol in rat plasma at each dose were well described by a two-compartment model.
T H, Tsai, C J, Chou, C F, Chen
openaire   +2 more sources

[Studies on absorption kinetics of paeonol and paeonol-beta-CD in rat's intestines].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
To explore the absorption mechanism of paeonol-beta-CD from various intestinal segments and offer biopharmaceutics data for paeonol new dosage form. The absorption kinetics and permeability rate consatants were investigated by the in situ perfusing method in rats.
Rong-Feng, Hu, Cheng-Wu, Fang, Ai-Feng, Zou, Kang-Kang, Mei, Ji-Hui, Tang, Ling-Ling, Han   +5 more
openaire   +1 more source

Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats

Neurochemical Research, 2019
Paeonol is the main active compound in the root bark extract of the peony tree, and it has antioxidative and anti-inflammatory effects. Recent studies have reported the neuroprotective effects of paeonol including its capacity in improving impaired memory. However, the effect of paeonol on epilepsy is yet to be demystified.
Dong-Hai, Liu, Elvis, Agbo, Shu-Hong, Zhang, Jin-Ling, Zhu   +3 more
openaire   +2 more sources