Results 131 to 140 of about 117,142 (268)

Cortical responses to balance perturbations persist without active postural control

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A robotic balance simulator was used to test whether cortical responses to balance perturbations are contingent on active balance control or instead reflect the detection of unexpected motion. Participants experienced identical support‐surface rotations (toes‐up and toes‐down) while actively controlling balance or while being ...
Daphne N. R. Jansen   +3 more
wiley   +1 more source

P2X7 receptors promote atrial remodeling and atrial fibrillation susceptibility via reactive oxygen species‐mediated mitogen‐activated protein kinase signaling activation

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Abstract Atrial fibrillation (AF), the most common clinical arrhythmia, is driven by inflammatory activation and oxidative stress, though precise molecular links remain unclear. This study identifies the P2X7 receptor as a key upstream regulator orchestrating proarrhythmic atrial remodeling through reactive oxygen species (ROS)‐mediated mitogen ...
Lingnan Zhang, Yeran Zhu, Xinshun Gu
wiley   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

open access: yesMedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong   +4 more
wiley   +1 more source

Transcranial Calcium Macro‐Imaging From the Auditory Cortex of Thy1‐Cre‐Driven GCaMP8 Transgenic Rats

open access: yesNeuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
We generated Thy1‐Cre–driven GCaMP8 transgenic rats by mating Thy1‐Cre rats with knock‐in rats carrying a floxed GCaMP8‐STOP cassette in the β‐actin locus. Robust neuronal GCaMP8 expression enabled transcranial calcium imaging of the auditory cortex, establishing this model as a powerful tool for minimally invasive cortical macro‐imaging and functional
Manavu Tohmi   +10 more
wiley   +1 more source

Interaction of Platelet Activating Factor Acetyl Hydrolase (PAF AH) Enzyme in G1n281->Arg281 Mutation Toward PAF and Its Molecular Dynamic

open access: yesJournal of Tropical Life Science, 2014
Platelet Activating Factor Acetyl Hydrolase (PAF AH) or LpPLA2 is a key enzyme in myocardial infarction catalyzes the sn-2 acetyl group of Platelet Activating Factor (PAF) into lyso PAF and acetate as non-potent inflammatory molecules ...
Jayarani Fatimah Putri   +2 more
doaj  

Development and Validation of the Professional Self‐Concept Scale for Hospital Nurses (PSCS‐HN)

open access: yesResearch in Nursing &Health, Volume 49, Issue 3, Page 269-282, June 2026.
ABSTRACT Professional self‐concept (PSC) has a positive influence on the attitudes and behaviors of members of an organization toward their work. Although establishing PSC is vital for nurses to provide quality nursing care, assessing PSC precisely in ever‐changing healthcare environments can be challenging.
Eun‐Ha Kim, Hye‐Ah Yeom
wiley   +1 more source

Development and Exploratory Validation of the Assisting Mealtime Scale for Dementia Care: Nursing Staff Perspectives on Mealtime Support

open access: yesNursing &Health Sciences, Volume 28, Issue 2, June 2026.
ABSTRACT Mealtime assistance for people living with dementia presents care‐related challenges, yet few validated instruments assess nursing staff perspectives. This study developed and conducted an exploratory validation of the Assisting Mealtime Scale.
Hansen Tang   +4 more
wiley   +1 more source

Development and Validation of the ClimHealth‐K: A Scale for Assessing Perceived Knowledge and Awareness of Climate Change‐Related Health Effects

open access: yesNursing &Health Sciences, Volume 28, Issue 2, June 2026.
ABSTRACT Climate change poses a significant threat to human health and is linked to various direct and indirect outcomes, including infectious diseases, heat‐related illnesses, and other climate‐sensitive conditions. However, standardized tools assessing perceived knowledge and awareness of climate‐related health effects remain limited.
Taha Gökmen Ülger   +4 more
wiley   +1 more source

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu   +11 more
wiley   +1 more source

Reliability and Validity of the Chinese Version of the Premenstrual Symptoms Screening Tool

open access: yesBrain and Behavior, Volume 16, Issue 5, May 2026.
The Chinese PSST was validated in 1366 female college students. It showed excellent reliability and validity, effectively distinguishing PMS/PMDD from healthy controls with a stable two‐factor structure. ABSTRACT Objective To evaluate the reliability and validity of the Chinese version of the Premenstrual Symptoms Screening Tool (PSST) in a sample of ...
Xue Li, Xiaochun Wang
wiley   +1 more source

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