Results 91 to 100 of about 10,132,612 (315)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Torres Strait Island men performing a dance as part of the Arpaka Dance Group, Thursday Island, Queensland, 2008, 1 [picture] /

, 2008
Title devised by cataloguer based on information from acquisition documentation.; Part of the collection: Arpaka Dance Group and Thursday Island infrastructure, Queensland, 2008.; Acquired in digital format; access copy available online.; Mode of access:
Page, Charles J. (Charles John), 1946-
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Potential resource and cost saving analysis of subcutaneous versus intravenous administration for rituximab in non-Hodgkin’s lymphoma and for trastuzumab in breast cancer in 17 Italian hospitals based on a systematic survey [Corrigendum]

ClinicoEconomics and Outcomes Research, 2017
Ponzetti C, Canciani M, Farina M, Era S, Walzer S. ClinicoEconomics and Outcomes Research. 2016;8:227–233.On page 230, Table 3, first column: The last time component should be: “Patient preparation time for eighteen cycles of therapy in ...
Ponzetti C, Canciani M, Farina M, Era S, Walzer S   +4 more
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Torres Strait Island women performing a dance as part of the Arpaka Dance Group, Thursday Island, Queensland, 2008 [picture] /

, 2008
Title devised by cataloguer based on information from acquisition documentation.; Part of the collection: Arpaka Dance Group and Thursday Island infrastructure, Queensland, 2008.; Acquired in digital format; access copy available online.; Mode of access:
Page, Charles J. (Charles John), 1946-
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Impact of Article Page Count and Number of Authors on Cita-tions in Disability Related Fields: A Systematic Review Article

Iranian Journal of Public Health, 2016
Background: Citation metrics and total publications in a field has become the gold standard for rating researchers and viability of a field. Hence, stimulating demand for citation has led to a search for useful strategies to improve performance metric ...
Abubakar AHMED, Mastura ADAM, Norafida A. GHAFAR, Murtala MUHAMMAD, Nader Ale EBRAHIM   +4 more
doaj  

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

STUDY ON CHANGES OF PROTEINS, ENZYMES AND CHROMOSOME NUMBER IN REGENERATED PLANTS OF WHEAT (TRITICUM AESTIVUM L.) [PDF]

Journal of Sciences, Islamic Republic of Iran, 2000
Somaclonal variation is one of the possible sources of variation in plant breeding. To evaluate the usefulness of somaclonal variation for creating variation in Iranian cultivars of wheat, proteins, enzymes and chromosome number of regenerated and seed ...
doaj