Results 71 to 80 of about 10,132,612 (315)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Jetty at Thursday Island, Queensland, 2008 [picture] /

, 2008
Title devised by cataloguer based on information from acquisition documentation.; Part of the collection: Arpaka Dance Group and Thursday Island infrastructure, Queensland, 2008.; Acquired in digital format; access copy available online.; Mode of access:
Page, Charles J. (Charles John), 1946-
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Angarsk as a Challenge for the East Asian Energy Community

The Mongolian Journal of International Affairs, 2013
The Mongolian Journal of International Affairs; Number 11, 2004, Page 104-128 DOI: http://dx.doi.org/10.5564/mjia.v0i11 ...
Gaye Christoffersen
doaj   +1 more source

Computer shop, Thursday Island, Queensland, 2008 [picture] /

, 2008
Title devised by cataloguer based on information from acquisition documentation.; Part of the collection: Arpaka Dance Group and Thursday Island infrastructure, Queensland, 2008.; Acquired in digital format; access copy available online.; Mode of access:
Page, Charles J. (Charles John), 1946-
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Northeast Asia Security and China's Role

The Mongolian Journal of International Affairs, 2013
The Mongolian Journal of International Affairs; Number 11, 2004, Page 55-74 DOI: http://dx.doi.org/10.5564/mjia.v0i11 ...
Men Jing, Gustaaf Geeraerts
doaj   +1 more source

Torres Strait Island boy performing a dance as part of the Arpaka Dance Group, Thursday Island, Queensland, 2008, 1 [picture] /

, 2008
Title devised by cataloguer based on information from acquisition documentation.; Part of the collection: Arpaka Dance Group and Thursday Island infrastructure, Queensland, 2008.; Acquired in digital format; access copy available online.; Mode of access:
Page, Charles J. (Charles John), 1946-
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Developing Nuclear Landscape in the Asian Heartland: Role of Nuclear-Weapon States

The Mongolian Journal of International Affairs, 2013
The Mongolian Journal of International Affairs; Number 11, 2004, Page 22-45 DOI: http://dx.doi.org/10.5564/mjia.v0i11 ...
J Enkhsaikhan
doaj   +1 more source