Results 31 to 40 of about 1,134,449 (313)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Recognizing DAGs with Page-Number 2 Is NP-complete

Theoretical Computer Science, 2023
Appears in the Proceedings of the 30th International Symposium on Graph Drawing and Network Visualization (GD 2022)
Michael A. Bekos, Giordano Da Lozzo, Fabrizio Frati, Martin Gronemann, Tamara Mchedlidze, Chrysanthi N. Raftopoulou   +5 more
openaire   +5 more sources

On the Banks of the Amazon [PDF]

, 2012
Published by Nelson, London. Page number(s) as given: not included in pagination.

core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Variability in grain, flour, functional properties and protein profiling in newly developed wheat genotypes grown in temperate climate of Western Himalayas

Frontiers in Nutrition
BackgroundSince wheat varieties and breeding lines developed by plant breeders in the western Himalayan region (Kashmir) have received limited attention with respect to their physical and protein quality characterization, the focus of the study is to ...
Taha Mukhtar, Abida Jabeen, Syed Zameer Hussain, Raashid Ahmad Siddiqi, Shabir H. Wani, Anju Mahendru-Singh, Tawheed Amin, Quraazah A. Amin, Mohmad Sayeed Bhat   +8 more
doaj   +1 more source

Phylogenetic relationships of some Egyptian soybean cultivars (Glycine max L.) using SCoT marker and protein pattern

Bulletin of the National Research Centre, 2019
Background Electrophoretic SDS-PAGE and SCoT-PCR techniques were used to study the fingerprints and genetic diversity of six Egyptian soybean (Glycine max L.) genotypes (Giza111, Giza21, Giza82, Giza35, Giza22, and Giza83).
Walaa A. Rayan, Samira A. Osman
doaj   +1 more source

Billows and Bergs [PDF]

, 2012
With original illustrations by Chas. J. de Lacy. Published by Frederick Warne, London. Page number(s) as given: not included in pagination.

core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Free Martingale polynomials for stationary Jacobi processes [PDF]

, 2007
We generalize a previous result concerning free martingale polynomials for the stationary free Jacobi process of parameters $\lambda \in ]0.1], \theta = 1/2$.
Demni, Nizar
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source