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Pathogenesis of Paget's Disease of Bone
Clinical Reviews in Bone and Mineral Metabolism, 2002Paget's disease of bone is a common condition characterised by increased and disorganised bone turnover which can affect one or several bones throughout the skeleton. These abnormalities disrupt normal bone architecture and lead to various complications such as bone pain osteoarthritis, pathological fracture, bone deformity, deafness, and nerve ...
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Genetics of Paget’s Disease of Bone
2000In 1877, Sir James Paget described a localized skeletal disorder affecting five patients over 40 yr of age, which he termed osteitis deformans (1). He chose this term for the disorder because of the deformities of his patients and the supposition that an unknown type of inflammatory process was responsible for its manifestations. His detailed and lucid
Frederick R. Singer, Robin J. Leach
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Bone Quality in Paget’s Disease of Bone
Current Osteoporosis Reports, 2016Paget's disease of bone is produced by a localized increase in osteoclastic and osteoblastic activity which can progress slowly to involve an entire bone if untreated. A common feature is enlarged bones which are deformed, particularly in weight-bearing regions of the skeleton such as the lower extremity.
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Sir James Paget: Paget's Disease of the Nipple, Paget's Disease of Bone
Journal of Perioperative Practice, 2013Sir James Paget was one of the ‘great’ Victorians. Eminent as a surgeon, pathologist and teacher, his nobility of character and application to his work made him a leader in his profession in that age of great men.
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