Results 71 to 80 of about 2,702,692 (201)
Exploring cellular changes in ruptured human quadriceps tendons at single‐cell resolution
The Journal of Physiology, EarlyView.Abstract figure legend This study explores the cellular landscape of healthy and ruptured quadriceps tendons using single nucleus RNA sequencing. While a range of stromal and immune cell types and subsets were identified, the data indicate that fibroblasts and endothelial cells are the main drivers of the early injury response within ruptured ...
Jolet Y. Mimpen +15 more
wiley +1 more source
International Journal of Cancer, Volume 156, Issue 11, Page 2178-2187, 1 June 2025.What's new? Bone metastases are common in a variety of cancer types, causing increased pain and worse outcomes. Suppression of bone turnover, such as with the monoclonal antibody denosumab, results in fewer skeletal complications and improved prognosis. Here, the authors demonstrate the safety and efficacy of a similar antibody, JMT103. Like denosumab,
Ran Ran +15 more
wiley +1 more source
Make Your Bone Great Again : A study on Osteoporosis Classification [PDF]
arXiv, 2017 Osteoporosis can be identified by looking at 2D x-ray images of the bone. The high degree of similarity between images of a healthy bone and a diseased one makes classification a challenge. A good bone texture characterization technique is essential for identifying osteoporosis cases.
arxiv
A lateral semicircular canal segmentation based geometric calibration for human temporal bone CT Image [PDF]
arXiv, 2020 Computed Tomography (CT) of the temporal bone has become an important method for diagnosing ear diseases. Due to the different posture of the subject and the settings of CT scanners, the CT image of the human temporal bone should be geometrically calibrated to ensure the symmetry of the bilateral anatomical structure.
arxiv
A rapidly growing breast tumour in a young woman
JEADV Clinical Practice, EarlyView.
K. A. Zub Carlsson +6 more
wiley +1 more source
Defeating lethal cancer: Interrupting the ecologic and evolutionary basis of death from malignancy
CA: A Cancer Journal for Clinicians, Volume 75, Issue 3, Page 183-202, May/June 2025.Abstract Despite the advances in cancer prevention, early detection, and treatments, all of which have led to improved cancer survival, globally, there is an increased incidence in cancer‐related deaths. Although each patient and each tumor is wholly unique, the tipping point to incurable disease is common across all patients: the dual capacity for ...
Kenneth J. Pienta +2 more
wiley +1 more source
An approach for the identification of targets specific to bone metastasis using cancer genes interactome and gene ontology analysis [PDF]
, 2011 Metastasis is one of the most enigmatic aspects of cancer pathogenesis and is a major cause of cancer-associated mortality. Secondary bone cancer (SBC) is a complex disease caused by metastasis of tumor cells from their primary site and is characterized by intricate interplay of molecular interactions.
arxiv +1 more source
Arthritis Care &Research, Volume 77, Issue 5, Page 604-613, May 2025.Objective Osteoporosis, a known complication of rheumatoid arthritis (RA), increases the risk of hip fracture, which is associated with high morbidity and mortality. Fracture risk estimates in patients with RA treated with contemporary treatment strategies are lacking.
C. Allyson Jones +5 more
wiley +1 more source
Bone Segmentation in Contrast Enhanced Whole-Body Computed Tomography [PDF]
arXiv, 2020 Segmentation of bone regions allows for enhanced diagnostics, disease characterisation and treatment monitoring in CT imaging. In contrast enhanced whole-body scans accurate automatic segmentation is particularly difficult as low dose whole body protocols reduce image quality and make contrast enhanced regions more difficult to separate when relying on
arxiv
Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective
The FEBS Journal, Volume 292, Issue 9, Page 2155-2172, May 2025.This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman +5 more
wiley +1 more source