LC–MS/MS application for urine free pyridinoline and free deoxypyridinoline: Urine markers of collagen and bone degradation [PDF]
Background: Pyridinium cross-links Pyridinoline (PYD) and Deoxypyridinoline (DPD) are established markers of collagen degradation. Measurement of PYD and DPD can be used to evaluate changes in bone turnover in patients with metabolic bone disease and to ...
Behrens +36 more
core +1 more source
Molecular Alterations in Osteosarcomas of the Oral and Maxillofacial Region: A Scoping Review
ABSTRACT Background Given the rarity and aggressive nature of osteosarcomas (OS) in the oral and maxillofacial region, understanding their molecular alterations is essential to improve diagnosis, prognosis, and guide targeted therapies. This study aimed to map molecular alterations associated with oral and maxillofacial OS, providing an overview of the
Iara Vieira Ferreira +6 more
wiley +1 more source
Difficulties in diagnosis and treatment of Paget’s disease
Paget’s disease is a rare finding in Poland. It is a disorder of the osteoarticular system, which, in adults, mostly affects people over 55 years of age.
Aleksandra Kawalec +2 more
doaj +1 more source
This study investigated the effect of spinal bone metastasis (BM) on the biomechanical environment of the spine through estimates of load, strength, and the load‐to‐strength ratio (LSR). Our study suggests that task‐specific differences related to cancer, lesion type, and vertebral location differentially affect the biomechanical environment of the ...
Dennis E. Anderson +13 more
wiley +1 more source
Fanconi Syndrome After a Single Exposure to Intravenous Zoledronic Acid
ABSTRACT Bisphosphonates are commonly used to reduce fracture risk in patients with osteoporosis, in those with malignant metastatic bone disease and for treatment of malignant hypercalcaemia. We present the case of a woman in her 80s admitted with recurrent falls who developed Fanconi syndrome after a single dose of intravenous Zoledronic acid despite
Rita Deb +2 more
wiley +1 more source
PAGET'S DISEASE: CURRENT TREATMENT MODALITIES
Paget's disease is a chronic local bone disease included into a group of metabolic osteopathies in which rearrangement foci emerge in one or several bones.
Yulia Leonidovna Korsakova
doaj +1 more source
Paget's disease of bone-associated osteosarcoma: molecular basis, signs and symptoms, treatment and research [PDF]
Darrell Green is a Big C-funded molecular biologist at the University of East Anglia, performing research towards a PhD. He works with Professor Tamas Dalmay, Head of Biological Sciences and Chair of RNA Biology at the University of East Anglia and ...
Dalmay, Tamas +2 more
core
A woman with raised alkaline phosphatase and forearm deformity [PDF]
published_or_final_versio
Chow, WS +5 more
core +1 more source
Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen +5 more
wiley +1 more source
Proteomic Signatures Over Age Reveal Significant Changes From Infancy Till Late Adulthood
Age‐specific changes in the serum proteome were investigated across the entire lifespan, from infancy till late adulthood by analyzing 178 proteins in serum samples of healthy individuals. Using various analyses approaches, distinct protein expression profiles and four protein patterns during aging were identified.
Eveline M. Delemarre +11 more
wiley +1 more source

