Results 61 to 70 of about 1,691 (205)

Glucocorticoid Receptor Activation Reprograms NK Cells to Drive AREG‐Mediated Immunosuppression: A Pan‐Cancer Role for AREG

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei, Guirong Liang, Rui zeng, Yuancheng Li, Anlan Hong, Hongsheng Wang, Suying Feng, Yan Wang, Yetao Wang   +8 more
wiley   +1 more source

Extramammary Paget's disease with the appearance of a nodule: a case report

BMC Cancer, 2010
Background Extramammary Paget's disease (EMPD) remains a rare condition with only a limited number of cases reported in the literature. EMPD is mainly composed of intraepidermal Paget cells, and possesses variable clinical behaviors and histological ...
Yang Jian, Yang Wenlin, Wang Xia
doaj   +1 more source

A case of extramammary inguinal Paget disease in a male patient: surgical treatment with an abdominal advancement cutaneous flap [PDF]

, 2017
Extramammary Paget disease (EMPD) is a rare neoplasm. The clinical case of a 55-year-old man with a two-year history of a pruritic, painless erythematous skin rash on the inguinal region and scrotum is described.
Brandi, Cesare, Cuomo, Roberto, D'Aniello, Carlo, Grimaldi, Luca, Milonia, Luca, Nisi, Giuseppe, Sisti, Andrea, Tassinari, Juri   +7 more
core   +1 more source

The Paget Trial:topical 5% imiquimod cream for noninvasive vulvar Paget disease [PDF]

, 2022
BACKGROUND: Vulvar Paget disease is an extremely rare skin disorder, which is most common in postmenopausal women. Most vulvar Paget disease cases are noninvasive; however, it may be invasive or associated with an underlying vulvar or distant ...
Boll, Dorry, Bulten, Johan, de Hullu, Joanne A., Esajas, Martha D., Meeuwis, Kim A., van Beurden, Marc, van der Linden, Michelle, van Dorst, Eleonora B., van Hees, Colette L., van Poelgeest, Mariette   +9 more
core   +4 more sources

Single‐Center Epidemiological Analysis of Malignant Transformation With Skin Ulcers in Outpatients

International Wound Journal, Volume 23, Issue 1, January 2026.
ABSTRACT Investigate the epidemiological characteristics of outpatients initially diagnosed with skin ulcers who were ultimately confirmed to have cutaneous malignant tumours, and provide a diagnostic and therapeutic basis for the occurrence of secondary diseases in chronic wounds.
Yaoyao Kong, Haixia Wang, Nan Cao, Pengcheng Huai, Zhenzhen Wang, Chaoqi Zuo, Xueqing Wang, Yilei Wu, Yongxia Liu, Shengli Chen, Hong Liu, Guangliang Zhang   +11 more
wiley   +1 more source

Paget’s disease derived in situ from reserve cell hyperplasia, squamous metaplasia, and squamous cell carcinoma of the esophagogastric junction: a case report

Surgical Case Reports, 2018
Background Extramammary Paget’s disease (EMPD) of the esophagus is a rare tumor, with most cases originating from invasive adenocarcinoma of the esophagus.
Akihiko Sano, Shinji Sakurai, Chika Komine, Yuichi Tabe, Kana Saito, Takaharu Fukasawa, Shinsuke Kiriyama, Hideki Yamamoto, Masachika Tani, Hiroshi Naitoh, Ken Shirabe, Hiroyuki Kuwano   +11 more
doaj   +1 more source

Comparison of the biomarkers for targeted therapies in primary extra-mammary and mammary Paget's disease. [PDF]

, 2020
Primary Extra-mammary Paget's disease (EMPD) is a very rare cutaneous adenocarcinoma affecting anogenital or axillary regions. It is characterized by a prolonged course with recurrences and eventually distant metastatic spread for which no specific ...
Choi, April, Contreras, Elma, Florento, Elena, Gatalica, Zoran, In, Gino K, Kacerovska, Denisa, Krušlin, Božo, Leary, Alexandra, Poorman, Kelsey, Senarathne, Wijendra, Stafford, Phillip, Vranic, Semir   +11 more
core   +1 more source

Re: Extramammary Paget disease - diagnostic and therapeutic challenges [PDF]

, 2023
NON
dos Santos, Vitorino M, Sugai, Taciana AM   +1 more
core   +2 more sources

First Case of Primary Breast Melanoma in Central America: Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Primary breast melanoma is an exceedingly rare neoplasm, accounting for < 0.5% of all malignant breast tumors. Its scarcity and highly variable clinical presentation often delay diagnosis and complicate management. We report the case of a 55‐year‐old woman with a primary non‐cutaneous melanoma of the right breast initially misdiagnosed as high‐
Ana García‐Urbina, Denis Espinoza‐Vásquez, Johanna Obregón‐Silva, Arlin Montoya Rodríguez   +3 more
wiley   +1 more source

Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Merkel Cell Carcinoma 2025

The Journal of Dermatology, Volume 52, Issue 11, Page e954-e967, November 2025.
ABSTRACT Merkel cell carcinoma (MCC) is a highly malignant skin cancer characterized by high rates of recurrence and metastasis. Although rare, the incidence has noticeably increased in recent years. It is also known to be a highly immunogenic tumor, and the use of immune checkpoint inhibitors has begun for advanced cases.
Motoki Nakamura, Kotaro Nagase, Junji Kato, Masahito Yasuda, Natsuo Tomita, Tadahiro Kobayashi, Keitaro Fukuda, Akihiko Yuki, Hiroshi Uchi, Hiroshi Koga, Tomomitsu Miyagaki, Yasuhiro Nakamura   +11 more
wiley   +1 more source