Results 81 to 90 of about 17,334 (244)

Mucosal Invasion, but Not Incomplete Excision, Has Negative Impact on Long-Term Survival in Patients With Extramammary Paget’s Disease

Frontiers in Oncology, 2021
Background Extramammary Paget’s disease (EMPD) sometimes spreads from the skin to mucosal areas, and curative surgical excision of these areas is challenging. The aim of this study is to analyze the impact of mucosal involvement and surgical treatment on
Hiroki Hashimoto, Y. Kaku‐Ito, M. Furue, Takamichi Ito   +3 more
semanticscholar   +1 more source

Paget’s disease derived in situ from reserve cell hyperplasia, squamous metaplasia, and squamous cell carcinoma of the esophagogastric junction: a case report

Surgical Case Reports, 2018
Background Extramammary Paget’s disease (EMPD) of the esophagus is a rare tumor, with most cases originating from invasive adenocarcinoma of the esophagus.
Akihiko Sano, Shinji Sakurai, Chika Komine, Yuichi Tabe, Kana Saito, Takaharu Fukasawa, Shinsuke Kiriyama, Hideki Yamamoto, Masachika Tani, Hiroshi Naitoh, Ken Shirabe, Hiroyuki Kuwano   +11 more
doaj   +1 more source

Integrative bioinformatics approaches to map key biological markers and therapeutic drugs in Extramammary Paget’s disease of the scrotum

PLoS ONE, 2021
Extramammary Paget’s disease (EMPD) is an intra-epidermal adenocarcinoma. Till now, the mechanisms underlying the pathogenesis of scrotal EMPD is poorly known.
F. Noor, M. Saleem, J. Chen, M. Javed, W. Al-Megrin, Sidra Aslam   +5 more
semanticscholar   +1 more source

Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Merkel Cell Carcinoma 2025

The Journal of Dermatology, Volume 52, Issue 11, Page e954-e967, November 2025.
ABSTRACT Merkel cell carcinoma (MCC) is a highly malignant skin cancer characterized by high rates of recurrence and metastasis. Although rare, the incidence has noticeably increased in recent years. It is also known to be a highly immunogenic tumor, and the use of immune checkpoint inhibitors has begun for advanced cases.
Motoki Nakamura, Kotaro Nagase, Junji Kato, Masahito Yasuda, Natsuo Tomita, Tadahiro Kobayashi, Keitaro Fukuda, Akihiko Yuki, Hiroshi Uchi, Hiroshi Koga, Tomomitsu Miyagaki, Yasuhiro Nakamura   +11 more
wiley   +1 more source

Extramammary Paget Disease in the Peristomal Skin of an Ileal Conduit Reconstructed With a Pedicled Anterolateral Thigh Flap

Plastic and Reconstructive Surgery, Global Open
Summary:. An ileal conduit is the most commonly used urinary diversion following radical cystectomy. Malignancy of the ileal conduit rarely occurs, and Paget disease has not been reported in the peristomal skin of an ileal conduit.
Makoto Shibuya, MD, Kou Fujisawa, MD, Yuichiro Yokoyama, MD, Kazuto Sasaki, MD, Soichiro Ishihara, MD, Hiroyuki Abe, MD, Mutsumi Okazaki, MD   +6 more
doaj   +1 more source

Comparison of the biomarkers for targeted therapies in primary extra-mammary and mammary Paget's disease. [PDF]

, 2020
Primary Extra-mammary Paget's disease (EMPD) is a very rare cutaneous adenocarcinoma affecting anogenital or axillary regions. It is characterized by a prolonged course with recurrences and eventually distant metastatic spread for which no specific ...
Choi, April, Contreras, Elma, Florento, Elena, Gatalica, Zoran, In, Gino K, Kacerovska, Denisa, Krušlin, Božo, Leary, Alexandra, Poorman, Kelsey, Senarathne, Wijendra, Stafford, Phillip, Vranic, Semir   +11 more
core   +1 more source

Serum Nectin‐4 as a Potential Prognostic Biomarker for Extramammary Paget Disease

Experimental Dermatology, Volume 34, Issue 10, October 2025.
ABSTRACT Nectin cell adhesion molecule 4 (Nectin‐4) is overexpressed in the tissue of extramammary Paget disease (EMPD), and its potential role as a circulating biomarker remains poorly explored. We therefore investigated serum levels of Nectin‐4 in EMPD patients and healthy controls by ELISA assay and analysed its clinical relevance.
Hiromichi Morita, Takuya Miyagawa, Kenta Oka, Okuto Iwasawa, Hinako Saito, Toko Mori, Hisao Kawashima, Jun Omatsu, Daisuke Yamada, Shinichi Sato   +9 more
wiley   +1 more source

Metastatic extramammary paget disease, a remarkable clinical case and a brief review of a rare disease

Dermatology Reports, 2020
Extramammary Paget Disease (EMPD) is an often-misdiagnosed rare disorder, whose cause remains unknown. Diagnosis is confirmed by skin biopsy. Primary treatment for EMPD is surgery.
Leonor Fernandes, Joana Graça, Leonor Vasconcelos de Matos, Rita Sampaio, Mafalda Miranda Baleiras, Filipa Ferreira, Marta Mesquita Pinto, Helena Miranda, Ana Martins   +8 more
doaj   +1 more source

Comprehensive management of vulvovaginal cancers

CA: A Cancer Journal for Clinicians, Volume 75, Issue 5, Page 410-435, September/October 2025.
Abstract Vulvar and vaginal cancers represent rare malignancies, with an incidence of 2.7 per 100,000 women for vulvar cancer, predominantly affecting women older than 60 years, although rising rates are observed in younger demographics. Approximately 90% of vulvar cancers are squamous cell carcinoma and frequently are associated with human ...
Angélica Nogueira‐Rodrigues, Maaike H. M. Oonk, Domenica Lorusso, Brian Slomovitz, Mario M. Leitão Jr, Glauco Baiocchi   +5 more
wiley   +1 more source

Acantholytic Anaplastic Extramammary Paget's Disease: A Case Report and Review of the Literature [PDF]

, 2011
Extramammary Paget's disease (EMPD) is an uncommon intraepithelial neoplasm that most commonly arises on the vulva and perianal region. Very few cases of EMPD revealing a histological Bowenoid appearance have been reported.
Bark-Lynn Lew, Cannavò, Hawley, Matsumoto, Mazoujian, Mobini, Orlandi, Quinn, Rayne, Williamson, Woo-Young Sim, Yu-Jin Oh   +11 more
core   +2 more sources