Results 41 to 50 of about 417,967 (303)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Validity and reliability of the Behavioural Observational Pain Scale for postoperative pain measurement in children 1-7 years of age

, 2007
Objective: Pain measurement is a necessity in pain treatment but can be difficult in young children. The aim of this study was to evaluate the validity and reliability of the Behavioural Observational Pain Scale (BOPS) as a postoperative pain measurement
Larsson, Sylvia, Romner, Bertil, Hesselgard, Karin, Reinstrup, Peter, Strömblad, Lars-Göran   +4 more
core   +2 more sources

Effectiveness of Self-etching Adhesive Only Versus in Combination with Gluma Desensitizer for Preventing Post-composite Sensitivity - A Prospective Study

Indian Journal of Dental Research
Introduction: An increase in the incidence of postoperative sensitivity following composite restorations has become an everyday clinical problem. The aim of this study was to evaluate and compare the clinical effectiveness of a self-etching adhesive in ...
Hemamalini Rath, Shilpa Mahapatra, Sri Priya Narayanan   +2 more
doaj   +1 more source

Multidimensional tools: application of pain quality cards in children Instrumentos multidimensionales: aplicación de las tarjetas de las cualidades del dolor en niños Instrumentos multidimensionais: aplicação dos cartões das qualidades da dor em crianças

Revista Latino-Americana de Enfermagem, 2006
This pilot, descriptive and field exploratory study aimed to verify the representative of the quality of pain, applying the Pain Quality Cards to 50 children and teenagers hospitalized in the first half of 2004, after being approved by the Ethic ...
Lisabelle Mariano Rossato, Fernanda Milani Magaldi   +1 more
doaj   +1 more source

Daily pain measurements and retrospective pain measurements in hip osteoarthrtitis patients with intermittent pain [PDF]

Osteoarthritis and Cartilage, 2018
ObjectiveTo examine the value of daily pain measurements in patients with hip osteoarthritis (OA), and whether the reliability of retrospective measurements was lower in patients with intermittent pain than in patients with more constant pain.MethodsWe used data from a randomized controlled trial that investigated the effectiveness of general ...
Carolien H. Teirlinck, Dieke S. Sonneveld, Sita M. A. Bierma‐Zeinstra, Pim A. J. Luijsterburg   +3 more
openaire   +4 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Do pain measurement instruments detect the effect of pain-reducing interventions in neonates? A systematic review on responsiveness

, 2019
: The effectiveness of pain-reducing interventions in newborns can only be determined if pain measurement instruments are responsive; i.e. able to detect a decrease in pain intensity after the pain-reducing intervention.
Meesters, N, van Dijk, Monique; id_orcid, Naomi Meesters, Meesters, Naomi, Dilles, T, Simons, SHP (Sinno), Simons, Sinno, Sinno Simons, Tinne Dilles, Monique van Dijk, Dilles, Tinne, van Dijk, Monique   +11 more
core   +1 more source

Effects of foam roller on pain intensity in individuals with chronic and acute musculoskeletal pain: a systematic review of randomized trials

BMC Musculoskeletal Disorders
Objective To analyze the effects of using foam roller on pain intensity in individuals with chronic and acute musculoskeletal pain. Methods This systematic review was registered in the National Institute for Health Research’s prospective online registry ...
Inaê Silva Santos, Almir Vieira Dibai-Filho, Patrícia Gabrielle dos Santos, José Djalma Arrais Júnior, Daniella Dias de Oliveira, Daniel Santos Rocha, Cid André Fidelis-de-Paula-Gomes   +6 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source