Results 51 to 60 of about 417,967 (303)

Short-term Outcomes and Quality of Life Following Surgical Treatment of Bimalleolar Ankle Fractures

Advanced Biomedical Research
Background: Bimalleolar ankle fractures, particularly those resulting from supination–external rotation (SER) mechanisms, are common injuries. This study evaluates the short-term clinical outcomes and quality of life following surgical treatment of these
Mehdi Teimouri, Hadi Ravanbod, Ashkan Salehi, Mohammad Shahsavan, Reza Yusofvand, Seyyed Reza Sharifzadeh, Akbar Hassanzadeh, Hossein Ranjbar   +7 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

PAIN MEASUREMENT AND MANAGEMENT IN PEOPLE WITH KNEE OSTEOARTHRITIS [PDF]

, 2013
The purpose of this thesis was to improve the understanding of pain measurement and management in people with knee OA through: 1) Developing a theoretical model that may help in pain management and measurement; 2) Exploring the knee OA individuals’ views
Negm, Ahmed M.
core  

Design, Development, and Verification of an Automated Pain Measurement Device

, 2013
The focus of this study is the redesign, development, fabrication, and initial evaluation of an automated pain measurement device. The redesign will focus on improving the original Computer Controlled Pressure Algometer, designed by Zimkowski in 2010 ...
Hill, Morgan L.
core   +2 more sources

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Pain measurement in arthritis [PDF]

Arthritis & Rheumatism, 1993
AbstractObjective. This paper reviews the major pain measurement methods used with adult patients with rheumatoid arthritis, osteoarthritis, and fibromyalgia.Methods and Results. The most frequently used measures are numerical and verbal rating (category) scales of pain intensity and affect.
openaire   +2 more sources

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

2D vs. 3D pain visualization: User preferences in a spinal cord injury cohort

, 2011
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2011 Springer VerlagResearch on pain experienced after Spinal Cord Injury (SCI) has revealed that not only are there several ...
Spyridonis, F, Ghinea, G, Gheorghita Ghinea, Fotios Spyridonis   +3 more
core   +1 more source

Dor durante o atendimento odontológico em unidades de saúde da família do município de Caruaru-PE

Revista Dor
JUSTIFICATIVA E OBJETIVOS: O medo de sentir dor pode retardar ou impedir a ida de pessoas ao dentista, sobretudo na população assistida pelas Estratégias de Saúde da Família.
Etenildo Dantas Cabral, Glissia Gisselle Alves, Gerlane Caitano de Souza   +2 more
doaj   +1 more source