Results 71 to 80 of about 936,333 (310)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Scales for pain assessment in cervical dentin hypersensitivity: a comparative study

Cadernos de Saúde Coletiva, 2020
Background Currently, different pain scales are used extensively to measure clinical pain, especially in dental practice. Objective This study aims to compare pain scales used in clinical research and dental practice, identifying the easiest to ...
Bethânia Lara Silveira Freitas, Marina de Souza Pinto, Evandro Silveira de Oliveira, Dhelfeson Willya Douglas-de-Oliveira, Endi Lanza Galvão, Patricia Furtado Gonçalves, Olga Dumont Flecha, Paulo Messias de Oliveira Filho   +7 more
doaj   +1 more source

Cardiac biomarkers by point-of-care testing - back to the future? [PDF]

, 2020
The measurement of the cardiac troponins (cTn), cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are integral to the management of patients with suspected acute coronary syndromes (ACS).
Collinson, P
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

An interactive 3-D application for pain management: Results from a pilot study in spinal cord injury rehabilitation [PDF]

, 2012
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 ElevierResearch on pain following spinal cord injury (SCI) has revealed that patients not only experience several types ...
Andrew O. Frank, Brooke, Bryce, Cardenas, Curtis, Duerstock, D’Amico, Ertürk, Felix, Fotios Spyridonis, Frank, Gheorghita Ghinea, Ghinea, Gibson, Giner-Pascual, Giner-Pascual, Greaves, Haefeli, Hickman, Jamison, Jan Gawronski, Kakol, Lang, Lee, Malliou, Mannion, Mitulescu, Mooney, Ohnmeiss, Ransford, Serif, Siddall, Siddall, Tsai, Wang   +34 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Penatalaksaan Fisioterapi Pada Kasus Low Back Pain Akibat Spondylosis Lumbalis Di RSUD Dr. Moewardi Surakarta [PDF]

, 2015
Background : Lower Back pain is one of the health problems that are common in the community. Causes of lower back pain include back pain spondilogenik involving changes in the soft tissues (discs, ligaments and muscles).
, Wahyuni, S.Fis, SKM, M. Kes, Puspitaningrum, Gita   +1 more
core  

Why and when social support predicts older adults’ pain-related disability [PDF]

, 2017
Pain-related social support has been shown to be directly associated with pain-related disability, depending on whether it promotes functional autonomy or dependence.
Bernardes, Sónia F., Goubert, Liesbet, Matos, Marta   +2 more
core   +2 more sources

Pain measurement in arthritis [PDF]

Arthritis & Rheumatism, 1993
AbstractObjective. This paper reviews the major pain measurement methods used with adult patients with rheumatoid arthritis, osteoarthritis, and fibromyalgia.Methods and Results. The most frequently used measures are numerical and verbal rating (category) scales of pain intensity and affect.
openaire   +2 more sources