Results 61 to 70 of about 3,927,088 (249)

Avaliação nociceptiva da associação entre exercício físico e fibrina rica em plaquetas em ratos Wistar submetidos ao modelo de compressão de nervo mediano

Revista Dor
RESUMO JUSTIFICATIVA E OBJETIVOS: Fibrina rica em plaquetas é uma técnica nova e promissora na aceleração do reparo, com possíveis efeitos analgésicos, contudo, ainda há uma lacuna com relação à lesão nervosa periférica, bem como com a associação com ...
Jhenifer Karvat, Camila Mayumi Martin Kakihata, Ana Luiza Peretti, Giovanni Ribeiro Bernardino, José Luis da Conceição Silva, Gladson Ricardo Flor Bertolini   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Scales for pain assessment in cervical dentin hypersensitivity: a comparative study

Cadernos de Saúde Coletiva, 2020
Background Currently, different pain scales are used extensively to measure clinical pain, especially in dental practice. Objective This study aims to compare pain scales used in clinical research and dental practice, identifying the easiest to ...
Bethânia Lara Silveira Freitas, Marina de Souza Pinto, Evandro Silveira de Oliveira, Dhelfeson Willya Douglas-de-Oliveira, Endi Lanza Galvão, Patricia Furtado Gonçalves, Olga Dumont Flecha, Paulo Messias de Oliveira Filho   +7 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Persistence of pain induced by startle and forehead cooling after sympathetic blockade in patients with complex regional pain syndrome [PDF]

, 2004
Background: Stimuli arousing sympathetic activity can increase ratings of clinical pain in patients with complex regional pain syndrome (CRPS). Objective: To determine whether the increase in pain is mediated by peripheral sympathetic activity.
Drummond, P.D., Finch, P.M.
core  

Using a New Measurement to Evaluate Pain Relief Among Cancer Inpatients with Clinically Significant Pain Based on a Nursing Information System: A Three-Year Hospital-Based Study

, 2016
Objective. Developing a new measurement index is the first step in evaluating pain relief outcomes. Although the percentage difference in pain intensity (%PID) is the most popular indicator, this indicator does not take into account the goal of pain ...
Liang, Chun-Yu, Wang, Kwua-Yun, Chu, Chi-Ming, Ho, Shung-Tai, Wang, Wei-Yun, Wu, Yi-Syuan, Sung, Chun-Sung   +6 more
core   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Pain measurement methods and pain measurement system design [PDF]

, 2023
The measurement of pain, which is one of the common problems of human beings, is extremely important in terms of determining the method and program that is planned to be applied to eliminate it.
Daldal, Nihat, Kurul, Ramazan, Caglar, Hakan   +2 more
core