Results 191 to 200 of about 3,287,582 (415)

A phase II study of neoadjuvant capecitabine, oxaliplatin, and irinotecan (XELOXIRI) in patients with locally advanced rectal cancer

open access: yesAnnals of Gastroenterological Surgery, Volume 7, Issue 1, Page 81-90, January 2023., 2023
XELOXIRI neoadjuvant chemotherapy appears to be feasible and efficacious for patients with LARC. Although neoadjuvant XELOXIRI alone did not yield our expected pCR rate, the local recurrence rate, 3‐year DFS and measures of safety met current standards.
Chu Matsuda   +16 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

open access: yesAdvanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang   +10 more
wiley   +1 more source

Frailty and surgical outcomes in gastrointestinal cancer: Integration of geriatric assessment and prehabilitation into surgical practice for vulnerable patients

open access: yesAnnals of Gastroenterological Surgery, Volume 7, Issue 1, Page 27-41, January 2023., 2023
Accumulating evidence demonstrates that the integration of preoperative geriatric assessment and prehabilitation for frail patients into clinical practice may improve perioperative and long‐term outcomes in patients with gastrointestinal cancer. We proposed an example for the integration of older patients‐specific care into treatment strategies for ...
Kosuke Mima   +4 more
wiley   +1 more source

Possibilities of attentional control of pain: influence of distractive Stroop task on pain threshold and pain tolerance [PDF]

open access: yes, 2006
Attention has been shown to modulate pain perception, but the relationship between attention and pain perception is still not clearly understood. Two independent experiments were conducted to examine the influence of focusing attention away from painful ...
Ivanec, Dragutin   +2 more
core   +1 more source

Neural Patterns of Social Pain in the Brain‐Wide Representations Across Social Contexts

open access: yesAdvanced Science, EarlyView.
Empathy arises from both physiological and social pain, yet their shared and context‐specific neural mechanisms remain unclear. Combining fMRI and multivariate pattern analysis, this study decodes overlapping empathy networks and distinct representations for social exclusion versus separation.
Xiaodong Zhang   +11 more
wiley   +1 more source

Prediction of need for bowel resection in acute superior mesenteric artery occlusion: A retrospective study of 48 Japanese patients

open access: yesAnnals of Gastroenterological Surgery, Volume 7, Issue 1, Page 175-181, January 2023., 2023
In a study of 48 patients with acute superior mesenteric artery occlusion, a logistic regression model using time from onset to diagnosis and the occlusion site of superior mesenteric artery showed 78.6% sensitivity in ruling out cases requiring bowel resection.
Susumu Watada   +9 more
wiley   +1 more source

Reference intervals and sources of variation of pressure pain threshold for quantitative sensory testing in a Japanese population. [PDF]

open access: yesSci Rep, 2023
Suzuki H   +12 more
europepmc   +1 more source

Microfluidics‐Based Microcarriers for Live‐Cell Delivery

open access: yesAdvanced Science, EarlyView.
In this review, recent advancements in microfluidics‐based microcarriers for live‐cell delivery are highlighted. The structural designs of microfluidic‐derived cell‐laden microcarriers are systematically categorized, emphasizing innovative approaches in the fabrication of microspheres, microfibers, and microneedles.
Zhonglin Fang   +3 more
wiley   +1 more source

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