Results 101 to 110 of about 176,534 (288)

Thresholds and Tolerance of Physical Pain Among Young Adults Who Self-Injure

Pain Research and Management, 2010
Prevalence rates of nonsuicidal self-injury among college students range from 17% to 38%. Research indicates that individuals with borderline personality disorder who self-injure sometimes report an absence of pain during self-injury.
Katrina McCoy, William Fremouw, Daniel W McNeil   +2 more
doaj   +1 more source

The effect of subcutaneous naloxone on experimentally induced pain

, 2008
The heat pain threshold was assessed in 32 healthy participants after a mild burn on the dorsal surface of each hand, after injection of an opioid antagonist (80 μg naloxone) or vehicle alone (0.2 mL saline) into the burnt skin of 1 hand, and after ...
Hammond, G.R., Drummond, P.D., Robertson, L.   +2 more
core  

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Racial differences in experimental pain sensitivity and conditioned pain modulation: a study of Chinese and Indians

Journal of Pain Research, 2019
Tze Siong NgDepartment of Rehabilitation, Physiotherapy Section, National University Hospital, Singapore, SingaporeBackground: Substantial literature has demonstrated racial differences in pain perception and endogenous pain modulation is proposed to be ...
Ng TS
doaj  

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

Advanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari   +8 more
wiley   +1 more source

Influence of estrogen levels on thermal perception, pain thresholds and pain tolerance : Studies on women undergoing in vitro fertilization

, 2012
We examined the relationship between estrogen and pain in women undergoing in vitro fertilization (IVF). Quantitative sensory tests (QST) were performed twice during the IVF-regimen: once during hormonal down-regulation and once during hormonal ...
Stening, Kent,, Hammar, Mats,, Mats Hammar, Amandusson, Asa,, Voster, Helene, Eriksson, Olle, Amandusson, Åsa, Helene Voster, Hammar, Mats, Voster, Helene,, Blomqvist, Anders,, Berg, Göran, Blomqvist, Anders, Berg, Göran,, Eriksson, Olle,, Göran Berg, Åsa Amandusson, Olle Eriksson, Kent D. Stening, Anders Blomqvist, Stening, Kent   +20 more
core   +1 more source

Neuroticism and pain catastrophizing aggravate response to pain in healthy adults:an experimental study [PDF]

, 2018
Background: The aim of this study was to investigate the association between neuroticism, pain catastrophizing, and experimentally induced pain threshold and pain tolerance in a healthy adult sample from two regions of the country of Croatia: the island ...
Marijana Bras, Banozic, Adriana, Kolcic, Ivana, Polasek, Ozren, Hayward, Caroline; id_orcid, Ozren Polasek, Livia Puljak, Puljak, Livia, Adriana Banozic, Bras, Marijana, Caroline Hayward, Miljkovic, Ana, Ana Miljkovic, Hayward, Caroline, Ivana Kolcic   +14 more
core   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source