Results 91 to 100 of about 867,900 (301)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
The Influence of the Changes in Urban Design on Contemporary Egyptian Painting
ARCHive-SR, 2017 The great cities in Egypt have been exposed to radical changes in its form and design since the second half of the Twentieth century. The study discusses these changes and their effect on the artistic production of the contemporary Egyptian painters. The
Reham Sherbiny
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The role of multiple materials to enrich contemporary mural painting
الاكاديميThe research presents a study on multiple materials and various media in enriching contemporary mural painting in a visual space that allows the formation of a perception enriches the aesthetic vision in the artistic work. Through the diversity of media
Ayad Abdulkareem Mayea +2 more
doaj +1 more source
Perceived Crowd Safety in Large Space Buildings: The Confirmatory Factor Analysis of Perceived Risk Variables [PDF]
Journal of Engineering, Project, and Production Management, 2018 In crowded large space buildings, safety is one of the most important concerns for facilities managers. Within the built environment, safety has been classified into two main parts: objective safety (normative and substantive) and subjective safety ...
Mohammed Alkhadim +2 more
doaj
Metaphors of opulence and power in the life of Thomas Wolsey, the King’s Cardinal [PDF]
, 2009 This essay approaches the display of power and rulership both through the art of writing and the art of painting by focusing on George Cavendish's biographical account of Thomas ...
Relvas, Maria de Jesus
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Silent Doorway to the Past: “Vigil” Painting in Weidensall Hall
, 2006 Every object has a story waiting to be told. There is one such artifact that hangs boldly on the mantle of the fireplace in Weidensall Hall its presence large and demanding. The plaque reads “‘The Vigil’ Presented in honor of Mrs. H.W.A.
Appenzeller, Elizabeth A.
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source