Simulated Results of a Passive Energy Retrofit Approach for Traditional Listed Dwellings in the UK
EnergiesEnergy performance improvements in existing homes play a substantial role in the achievement of the UK’s net-zero emissions target. However, retrofitting dwellings remains a particularly challenging task in the UK, where traditional dwellings make up a ...
Michela Menconi +2 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Zeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-BiałejThis article analyzes how paints and coatings businesses in the USA and Kazakhstan scale between 2019 and 2023. The research employs a non-linear econometric model to identify key factors, including market size, innovation, supply chain efficiency and ...
Andrey Chshelokovskiy
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Necessity and Use of a Multilayer Test Object Based on an Anonymous 19th Century Copy of a Painting by Ivan Konstantinovich Aivazovsky (1817–1900) [PDF]
, 2022 Ivan I. Andreev +7 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Designing and evaluating the efficacy of interactive drawing methods based on parent-child relationship on the symptoms of separation anxiety disorder in 6-8 year old children [PDF]
مجله علوم روانشناختیBackground: Separation anxiety disorder is one of the most common psychological disorders in childhood. Parenting styles and parental anxiety are among the important risk factors that have been identified for the occurrence of separation anxiety disorder.
Nooshin Torabi Goodarzi +2 more
doaj
Natural Temperature—Regional Oil Paintings by Russian Contemporary Artist Vagin Evgeny
, 2023 H. Q. Wang
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source