Results 71 to 80 of about 884,774 (339)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Perceived Crowd Safety in Large Space Buildings: The Confirmatory Factor Analysis of Perceived Risk Variables [PDF]
Journal of Engineering, Project, and Production Management, 2018 In crowded large space buildings, safety is one of the most important concerns for facilities managers. Within the built environment, safety has been classified into two main parts: objective safety (normative and substantive) and subjective safety ...
Mohammed Alkhadim +2 more
doaj
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
SECULAR GREEK MIGRATION TO RUSSIA of the END OF XVI – FIRST HALF XVII CENTURIES
Vestnik MGIMO-Universiteta, 2017 The article is devoted to the issue of migration in Russia in the Early-modern time the Orthodox subjects of the Ottoman Empire and its vassal States.
T. A. Oparina
doaj +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Estimation of Scribble Placement for Painting Colorization [PDF]
, 2013 Image colorization has been a topic of interest since the mid 70’s and several algorithms have been proposed that given a grayscale image and color scribbles (hints) produce a colorized image. Recently, this approach has been introduced in the field of
Rusu, Cristian, Tsaftaris, Sotirios A.
core +1 more source
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source
Genetic Paint: A Search for Salient Paintings
, 2005 The contribution of this paper is a novel non-photorealistic rendering (NPR) algorithm for rendering real images in an impasto painterly style. We argue that figurative artworks are salience maps, and develop a novel painting algorithm that uses a genetic algorithm (GA) to search the space of possible paintings for a given image, so approaching an ...
Collomosse, JP +12 more
openaire +4 more sources