Results 51 to 60 of about 1,014 (217)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The influence of pair duration on reproductive success in the monogamous ‘Alalā (Hawaiian crow, Corvus hawaiiensis)

Frontiers in Conservation Science
Conservation breeding program practitioners select potential mates in an attempt to maximize pair compatibility and maintain genetic diversity. Therefore, pair duration, or the number of breeding seasons that individuals retain the same mate, is ...
Lisa P. Barrett, Alison M. Flanagan, Bryce Masuda, Ronald R. Swaisgood   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Sexual coordination in a whole-brain map of prairie vole pair bonding

eLife
Sexual bonds are central to the social lives of many species, including humans, and monogamous prairie voles have become the predominant model for investigating such attachments.
Morgan L Gustison, Rodrigo Muñoz-Castañeda, Pavel Osten, Steven M Phelps   +3 more
doaj   +1 more source

Crystal structure of O-isopropyl [bis(trimethylsilyl)amino](tert-butylamino)phosphinothioate

Acta Crystallographica Section E: Crystallographic Communications, 2015
[Bis(trimethylsilyl)amino](tert-butylimino)thiophosphorane reacts in benzene with isopropyl alcohol via 1,2-addition of an iPrO–H bond across the P=N bond, resulting in the title compound, C13H35N2OPSSi2. In the molecule, the P atom possesses a distorted
Oleksandr O. Kovalenko, Vasyl Kinzhybalo, Oleksii A. Brusylovets, Tadeusz Lis   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Bis[bis(diphenylphosphinoyl)acetonitrile-κ2O,O′]copper(II)

Acta Crystallographica Section E, 2011
The title complex, [Cu(C26H20NO2P2)2], contains a central CuII atom surrounded by two homoleptic bidentate ligands, which form two five-membered chelate rings. The Cu atom binds to four O atoms, resulting in a four-coordinate square-planar complex.
Sicelo V. Sithole, Richard J. Staples, Werner E. Van Zyl   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source