Results 31 to 40 of about 403,679 (224)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial.

PLoS Medicine, 2017
BACKGROUND:Although the generic drug approval process has a long-term successful track record, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as tacrolimus, in transplant recipients.
Rita R Alloway, Alexander A Vinks, Tsuyoshi Fukuda, Tomoyuki Mizuno, Eileen C King, Yuanshu Zou, Wenlei Jiang, E Steve Woodle, Simon Tremblay, Jelena Klawitter, Jost Klawitter, Uwe Christians   +11 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Oscillatory activity in bilateral prefrontal cortices is altered by distractor strength during working memory processing

NeuroImage
Working memory (WM) enables the temporary storage of limited information and is a central component of higher order cognitive function. Irrelevant and/or distracting information can have a negative impact on WM processing and suppressing such incoming ...
Megan C. Hall, Maggie P. Rempe, Ryan J. Glesinger, Lucy K. Horne, Hannah J. Okelberry, Jason A. John, Christine M. Embury, Elizabeth Heinrichs-Graham, Tony W. Wilson   +8 more
doaj   +1 more source

CA1-projecting subiculum neurons facilitate object-place learning. [PDF]

, 2019
Recent anatomical evidence suggests a functionally significant back-projection pathway from the subiculum to the CA1. Here we show that the afferent circuitry of CA1-projecting subicular neurons is biased by inputs from CA1 inhibitory neurons and the ...
Chen, Lujia, Golshani, Peyman, Holmes, Todd C, Jiang, Li, Jin, Suoqin, Johnston, Kevin G, Lin, Xiaoxiao, Nie, Qing, Nitz, Douglas A, Qiao, Xin, Sun, Yanjun, Xu, Xiangmin, Zhou, Pengcheng   +12 more
core   +1 more source

Dropout Model Evaluation in MOOCs

, 2018
The field of learning analytics needs to adopt a more rigorous approach for predictive model evaluation that matches the complex practice of model-building.
Brooks, Christopher, Gardner, Josh
core   +1 more source

Apraxia and motor dysfunction in corticobasal syndrome [PDF]

, 2014
Background: Corticobasal syndrome (CBS) is characterized by multifaceted motor system dysfunction and cognitive disturbance; distinctive clinical features include limb apraxia and visuospatial dysfunction. Transcranial magnetic stimulation (TMS) has been
A Alberici, A Kertesz, A Kertesz, A Zwinkels, AA Kühn, AK Holl, Alessio Avenanti, B Borroni, B Okuda, BF Boeve, BF Boeve, BP Shelley, C Zadikoff, CD Good, D Claus, D Rueckert, DS Margulies, E De Renzi, E Frasson, E Mioshi, ED Huey, G Goldenberg, G Goldenberg, G Pengas, H Ling, J Ashburner, J Gottlieb, J Rohrer, J Valls-Solé, James R. Burrell, JL Whitwell, JM Cedarbaum, JO Rinne, John R. Hodges, JR Burrell, JR Burrell, JR Burrell, JR Burrell, K Tsuchiya, KA Josephs, KY Haaland, LJ Buxbaum, LJG Rothi, LR Robinson, M Heath, M Hornberger, M Pazzaglia, Matthew C. Kiernan, MC Kiernan, Michael Hornberger, NL Graham, NL Graham, P Soliveri, PK Pal, PP Pramstaller, PS Mathuranath, QJ Almeida, R Cantello, R Chen, R Leiguarda, R Leiguarda, R Mathew, R Mathew, RG Gross, RJ Fisher, RT Watson, S Vucic, S Vucic, S Vucic, S Vucic, SE Lee, SM Smith, SM Smith, Steve Vucic, T Fukui, U Ziemann, V Di Lazzaro, V Stamenova, Y Okuma, Y Zhang   +79 more
core   +3 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes

BMC Cancer
Background Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-characterized group of
Tabitha A. Harrison, Syed H. Zaidi, Hang Yin, Robert S. Steinfelder, Conghui Qu, Elom K. Aglago, Sonja I. Berndt, Lisa A. Boardman, Hermann Brenner, Daniel D. Buchanan, Peter T. Campbell, Yin Cao, Andrew T. Chan, Stephen J. Chanock, Kimberly F. Doheny, David A. Drew, Jane C. Figueiredo, Amy J. French, Steven Gallinger, Peter Georgeson, Marios Giannakis, Ellen L. Goode, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Sophia Harlid, Michael Hoffmeister, Wen-Yi Huang, Meredith AJ. Hullar, Jeroen R. Huyghe, Mark A. Jenkins, Yi Lin, Victor Moreno, Neil Murphy, Polly A. Newcomb, Christina C. Newton, Jonathan A. Nowak, Mireia Obón-Santacana, Shuji Ogino, Tameka Shelford, Mingyang Song, Claire E. Thomas, Amanda E. Toland, Tomotaka Ugai, Caroline Y. Um, Bethany Van Guelpen, Quang M. Trinh, Wei Sun, Thomas J. Hudson, Li Hsu, Ulrike Peters, Amanda I. Phipps   +51 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source