Results 31 to 40 of about 169,356 (242)

Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes

BMC Cancer
Background Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-characterized group of
Tabitha A. Harrison, Syed H. Zaidi, Hang Yin, Robert S. Steinfelder, Conghui Qu, Elom K. Aglago, Sonja I. Berndt, Lisa A. Boardman, Hermann Brenner, Daniel D. Buchanan, Peter T. Campbell, Yin Cao, Andrew T. Chan, Stephen J. Chanock, Kimberly F. Doheny, David A. Drew, Jane C. Figueiredo, Amy J. French, Steven Gallinger, Peter Georgeson, Marios Giannakis, Ellen L. Goode, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Sophia Harlid, Michael Hoffmeister, Wen-Yi Huang, Meredith AJ. Hullar, Jeroen R. Huyghe, Mark A. Jenkins, Yi Lin, Victor Moreno, Neil Murphy, Polly A. Newcomb, Christina C. Newton, Jonathan A. Nowak, Mireia Obón-Santacana, Shuji Ogino, Tameka Shelford, Mingyang Song, Claire E. Thomas, Amanda E. Toland, Tomotaka Ugai, Caroline Y. Um, Bethany Van Guelpen, Quang M. Trinh, Wei Sun, Thomas J. Hudson, Li Hsu, Ulrike Peters, Amanda I. Phipps   +51 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Paired analysis between the different conditions.

, 2015
Italic = p-value
Petra Leidinger (191756), Andreas Keller (29147), Eckart Meese (46359), Christina Backes (34966), Stefanie Rheinheimer (829701)   +4 more
core   +1 more source

Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial.

PLoS Medicine, 2017
BACKGROUND:Although the generic drug approval process has a long-term successful track record, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as tacrolimus, in transplant recipients.
Rita R Alloway, Alexander A Vinks, Tsuyoshi Fukuda, Tomoyuki Mizuno, Eileen C King, Yuanshu Zou, Wenlei Jiang, E Steve Woodle, Simon Tremblay, Jelena Klawitter, Jost Klawitter, Uwe Christians   +11 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Pillars of judgment : how memory abilities, task feedback, and cognitive load guide judgment strategies [PDF]

, 2014
Making judgments is an essential part of everyday life and how people form a judgment has instigated a plethora of research. Research in judgment and categorization has particularly contrasted two types of judgment strategies: rule-based and similarity-
Hoffmann, Janina Anna
core   +1 more source

Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability

, 2021
Consolation is a common response to the distress of others in humans and some social animals, but the neural mechanisms underlying this behavior are not well characterized.
Li, Lai-Fu, Tai, Fa-Dao
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Paired comparisons in ANOVA

, 2022
Problém testování více hypotéz najednou se nazývá problém mnohonásob- ného testování. Zaměřili jsme se na porovnávání více než dvou středních hod- not v analýze jednoduchého třídění, známé také jako ANOVA.
Hrušková, Iveta
core  

Zero- vs. one-dimensional, parametric vs. non-parametric, and confidence interval vs. hypothesis testing procedures in one-dimensional biomechanical trajectory analysis. [PDF]

, 2015
Biomechanical processes are often manifested as one-dimensional (1D) trajectories. It has been shown that 1D confidence intervals (CIs) are biased when based on 0D statistical procedures, and the non-parametric 1D bootstrap CI has emerged in the ...
Robinson, Mark A, Pataky, TC, Vanrenterghem Jos, Robinson Mark A, Vanrenterghem, J, Robinson, MA, Vanrenterghem, Jos, Pataky Todd C, Pataky, Todd C   +8 more
core   +1 more source