Results 61 to 70 of about 169,356 (242)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Thurstonian Covariance and Correlation Structures for Multiple Judgment Paired Comparison Data [PDF]
(WP 04/03 Clave pdf) Thurstone´s (1927) is not a proper model for multiple judgment paired comparison data as it assigns zero probabilities to all intransitive patterns.
ALBERTO MAYDEU
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Corrections to classical procedures for estimating thurstone´s case v model for ranking data [PDF]
The classical method (Mosteller, 1951) for estimating Thurstone´s Case V model for ranking data consists in a) transforming the observed ranking patterns to patterns of binary paired comparisons, b) obtaining the normal deviate corresponding to the men ...
ALBERTO MAYDEU
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Modeling Preference Data [PDF]
We provide a gentle overview of modeling choice data, with an emphasis on statistical models that allow treating both observed and unobserved effects due to the decision makers and choice options.
ALBERTO MAYDEU
core
Enhancing the soft proofing paradigm [PDF]
, 2007 The first part of this study is devoted to assessing the suitability of soft proofs as a surrogate for the final print in judging colour-reproduction quality. Two sets of psychophysical experiments were carried out.
Gatt, Alexis
core
Selection of dynamic biomarker candidates.
, 2015 For selection of dynamic biomarker candidates, MFC, log2(MFC), P-value, and-log10(P-value) are summarized for each metabolite in the table. The majority of metabolites show a positive value for log2(MFC), where only two metabolites, namely carnitine (C0)
Marc Breit (789355) +3 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source