Results 91 to 100 of about 359,596 (298)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Data from: Eggshells as hosts of bacterial communities: an experimental test of the antimicrobial egg coloration hypothesis

, 2017
Oviparous animals have evolved multiple defenses to prevent microbes from penetrating their eggs and causing embryo mortality. In birds, egg constituents such as lysozyme and antibodies defend against microbial infestation, but eggshell pigments might ...
Donald C. Dearborn, Hauber, Mark E., Mark E. Hauber, Miri Dainson, Daniel Hanley, Dainson, Miri, Symmantha M. Page, Hanley, Daniel, Dearborn, Donald C, Dearborn, Donald C., Page, Symmantha M.   +10 more
core   +2 more sources

TEACHING READING COMPREHENSION IN RECOUNT TEXT BY USING ZOOMING IN AND ZOOMING OUT (ZIZO) STRATEGY TO THE EIGHTH GRADE STUDENTS OF SMP SRIGUNA PALEMBANG

Edukasi: Jurnal Pendidikan dan Pengajaran, 2016
There are two purposes of this study. First, to find out whether or not there is a significant difference on the eighth grade students’ recount reading between those who are taught by using Zooming In and Zooming Out (ZIZO) strategy and those who are not
Ekha yasthi
doaj  

SMART-KU Module Based on Local Wisdom in Problem-Based Learning on Mathematical Problem-Solving Ability of Elementary School Students: An Experimental Study

Jurnal Teknologi Pendidikan
Mathematical problem-solving ability is an important ability for students to master, but it is often not facilitated due to the lack of use of adequate teaching materials and learning models.
Fitriyah Amaliyah, Fatikhatun Najikhah, Wulan Sutriyani, Femas Anggit Wahyu Nugroho, Otto Fajarianto   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Optimizing joint mobility and muscle elasticity through gymnastics exercises at high school students

Annals of the “Ştefan cel Mare” University: Physical Education and Sport Section - The Science and Art of Movement
This study evaluated the effectiveness of integrating specific gymnastic exercises and active-dynamic/PNF stretching into high school PE to enhance joint mobility and muscle elasticity.
Moncea Constantin Emilian, Leuciuc Florin   +1 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Eat or be eaten: Implications of potential exploitative competition between wolves and humans across predator- savvy and -naive deer populations

, 2023
<p>Recolonization of predators to their former ranges is becoming increasingly prevalent. Such recolonization places predators amongst their prey once again; the latter having lived without predation (from such predators) for considerable time ...
Bump, Joseph, Chakrabarti, Stotra, Candler, Ellen, Severud, William   +3 more
core   +1 more source