Results 81 to 90 of about 359,596 (298)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Calming the Mind, Sharpening Focus: The Role of Murattal Al-Qur'an in Students’ Concentration

Anfusina: Journal of Psychology
The effectiveness of the learning process is not only determined by grades but also depends on an individual's capacity for concentration and focus.
Muhamad Antos Riady, Nur Tazkia, Sakinah Alvian Rahmi, Rila Renita Susanti, Okka Lusyiawati   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 in human skeletal muscle

, 2014
We investigated the phosphorylation signatures of two Rab GTPase activating proteins TBC1D1 and TBC1D4 in human skeletal muscle in response to physical exercise and physiological insulin levels induced by a carbohydrate rich meal using a paired ...
Schjerling, Peter, Wojtaszewski, Jørgen, Birk, Jesper Bratz, Pehmøller, Christian, Kristensen, Jonas Møller, Kjøbsted, Rasmus, Goodyear, Laurie J, Richter, Erik A., Treebak, Jonas Thue   +8 more
core   +1 more source

Model-based analysis of experimental data from interconnected, row-configured huts elucidates multifaceted effects of a volatile chemical on Aedes aegypti mosquitoes [PDF]

, 2018
Background Insecticides used against Aedes aegypti and other disease vectors can elicit a multitude of dose-dependent effects on behavioral and bionomic traits.
Achee, Nicole L., Quirine A. ten Bosch, Perkins, T Alex, Morrison, Amy C., John P. Grieco, Grieco, John P., Perkins, T.A., T. Alex Perkins, Manda, Hortance, Ten Bosch, Quirine A., Nicole L. Achee, ten Bosch, Quirine A, Grieco, John P, Hortance Manda, Fanny Castro-Llanos, Morrison, Amy C, Achee, Nicole L, Amy C. Morrison, Castro-Llanos, Fanny   +18 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Nature vs. Nurture: Defining the Effects of Mesenchymal Stromal Cell Isolation and Culture Conditions on Resiliency to Palmitate Challenge [PDF]

, 2019
As MSC products move from early development to clinical translation, culture conditions shift from xeno- to xeno-free systems. However, the impact of isolation and culture-expansion methods on the long-term resiliency of MSCs within challenging ...
Maria K. Frazer, Anthony J. Burand, Lauren K. Boland, Devlin T. Boyt, Hannah Dobroski, Donna A. Santillan, James A. Ankrum, Michael V. Schrodt, Lin Di, Jesse N. Liszewski   +9 more
core   +1 more source

Penerapan teknik cynema therapy untuk meningkatkan pemahaman siswa terhadap bahaya merokok

Jurnal Psikologi Pendidikan dan Konseling, 2017
the purpose of the study is to know the application of cinema therapy techniques that can improve students' understanding to the dangers of smoking at SMP Muhammadiyah Palangkaraya. This research is a quantitative experimental approach.
Muhammad Fatchurahman
doaj