Results 81 to 90 of about 23,346,457 (282)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Efficient SIMD Implementation of the BLS Signature Scheme Using Intel AVX-512

Transactions on Cryptographic Hardware and Embedded Systems
The BLS digital signature scheme, in particular its instantiation with the BLS12-381 curve, has become a cornerstone of modern blockchain protocols such as Ethereum Proof-of-Stake, due to its unique and attractive characteristics (e.g., support for non ...
Ganqin Liu, Hao Cheng, Georgios Fotiadis, Jipeng Zhang, Johann Großschädl   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Identity-Based Cryptosystem Based on Tate Pairing [PDF]

, 2016
Tate Pairings on Elliptic curve Cryptography are important because they can be used to build efficient Identity-Based Cryptosystems as well as their implementation essentially determines the efficiency of cryptosystems In this work we propose an ...
K Venugopal Rao, D Vasumathi, Ramesh Ch
core   +2 more sources

Hadamard Product Arguments and Their Applications

IEEE Access
The Hadamard product (also known as element-wise multiplication) is a fundamental operation in linear algebra, performed by multiplying corresponding elements of two matrices with the same dimensions. This operation plays a crucial role in various fields,
Kyeongtae Lee, Hankyung Ko, Donghwan Oh, Jihye Kim, Hyunok Oh   +4 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Pairing-Based Cryptography: Past, Present, and Future [PDF]

, 2012
While pairings were first introduced in cryptography as a tool to attack the discrete-log problem on certain elliptic curves, they have since found numerous applications in the construction of cryptographic systems. To this day many problems can only be solved using pairings.
openaire   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Generating pairing-friendly elliptic curve parameters using sparse families

Journal of Mathematical Cryptology, 2018
The majority of methods for constructing pairing-friendly elliptic curves are based on representing the curve parameters as polynomial families. There are three such types, namely complete, complete with variable discriminant and sparse families. In this
Fotiadis Georgios, Konstantinou Elisavet
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source