Results 81 to 90 of about 12,868 (287)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Enhancing an Embedded Processor Core with a Cryptographic Unit for Performance and Security [PDF]

, 2008
We present a set of low-cost architectural enhancements to accelerate the execution of certain arithmetic operations common in cryptographic applications on an extensible embedded processor core.
Kocabas, Ovunc, Kocabaş, Övünç, Savas, Erkay, Savaş, Erkay   +3 more
core  

On finite fields for pairing based cryptography

Advances in Mathematics of Communications, 2007
Here, we improve our previous bound on the number of finite fields over which elliptic curves of cryptographic interest with a given embedding degree and small complex multiplication discriminant may exist. We also give some heuristic arguments which lead to a lower bound which in some cases is close to our upper bound.
Florian Luca, Igor Shparlinski
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Hadamard Product Arguments and Their Applications

IEEE Access
The Hadamard product (also known as element-wise multiplication) is a fundamental operation in linear algebra, performed by multiplying corresponding elements of two matrices with the same dimensions. This operation plays a crucial role in various fields,
Kyeongtae Lee, Hankyung Ko, Donghwan Oh, Jihye Kim, Hyunok Oh   +4 more
doaj   +1 more source

On the Relations Between Diffie-Hellman and ID-Based Key Agreement from Pairings [PDF]

, 2009
This paper studies the relationships between the traditional Diffie-Hellman key agreement protocol and the identity-based (ID-based) key agreement protocol from pairings.
Wang, Shengbao
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Generating pairing-friendly elliptic curve parameters using sparse families

Journal of Mathematical Cryptology, 2018
The majority of methods for constructing pairing-friendly elliptic curves are based on representing the curve parameters as polynomial families. There are three such types, namely complete, complete with variable discriminant and sparse families. In this
Fotiadis Georgios, Konstantinou Elisavet
doaj   +1 more source