Results 81 to 90 of about 3,573,148 (246)
Physics OpenWe propose two-gate extensions of the sequential single-qubit optimizers, Free Axis Selection (Fraxis) and Free Quaternion Selection (FQS), termed Two-Gate Fraxis (TGF) and Two-Gate FQS (TGFQS), respectively.
Joona V. Pankkonen
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Columbus Free Press newsletter
, 1978 Newsletter sent to Columbus Free Press staff and volunteers, documenting the current financial status of the newspaper and relevant news. The Columbus Free Press began as a bi-weekly publication in Columbus, Ohio, in 1970.
Columbus Free Press (Publisher)
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Pairing and thermodynamics properties of finite-systems with fixed number of particles
EPJ Web of Conferences, 2012 A canonical description of the thermodynamical pairing properties of small systems is achieved by using the Variation After Projection approach at finite temperature.
Gambacurta D., Lacroix D.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Columbus Free Press subscription form
, 1990 Order form encouraging subscription to and financial support for the Columbus Free Press. It also announces that the newspaper will no longer be available for free, but can be obtained by subscription or for $1 per copy at Free Press newsboxes.
Columbus Free Press (Publisher)
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A pairing-free identity-based cryptosystem
, 2021 Thesis (Ph.D. (Computer Science and Information Systems))--National Institute of Development Administration, 2021ID-based cryptosystems (IBCs) allow the use of publicly identifiable information in public encryption keys, which reduces the overhead of ...
Poonsuk Ponpurmpoon
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
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IEEE AccessWith the advancement of modern healthcare systems, patients now utilize medical sensor nodes to generate health data. These data are then transmitted to healthcare providers for analysis and diagnosis of the patient.
Moirangthem Rabindra Singh +4 more
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