Results 81 to 90 of about 178,160 (309)

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Translation and cultural adaptation of the Integrated Palliative care Outcome Scale including cognitive interviewing with patients and staff

BMC Palliative Care, 2017
Background To expand our clinical and scientific knowledge about holistic outcomes within palliative care, there is a need for agreed-upon patient-reported outcome measures.
Ingela Beck, Ulrika Olsson Möller, Marlene Malmström, Anna Klarare, Henrik Samuelsson, Carina Lundh Hagelin, Birgit Rasmussen, Carl Johan Fürst   +7 more
doaj   +1 more source

Experiences of a Novel Integrated Service for Older Adults at Risk of Frailty: A Qualitative Study

Journal of Patient Experience, 2023
The UK has a significant and growing population of older adults with frailty and complex healthcare needs, necessitating innovative care solutions. This study aimed to explore patients’ and carers’ experiences of a novel integrated service that was set ...
Imogen Wilson MSc, Blessing O Ukoha-kalu PhD, Mabel Okoeki PhD, Joseph Clark PhD, Jason W Boland PhD, Sophie Pask MSc, Ugochinyere Nwulu MSc, Helene Elliott-Button PhD, Anna Folwell MBChB, Miriam J Johnson MD, Daniel Harman MBChB, Fliss EM Murtagh PhD   +11 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Multicomponent Interventions for Adults With Cancer Cachexia: A Systematic Review

Journal of Cachexia, Sarcopenia and Muscle
Background Cancer cachexia has substantial impacts on people's quality of life. There is no current gold standard treatment, but the complex pathophysiology of cachexia suggests that a multitargeted and individualised treatment approach is needed.
Megan Bowers, Carmine Petrasso, Amy McLuskie, Joanne Bayly, Barry J. A. Laird, Irene J. Higginson, Matthew Maddocks   +6 more
doaj   +1 more source

Mobile Palliative Care Consultation Service (PCCS): Overview of Hospice and Palliative Care Evaluation (HOPE) Data on In-Patients With End-Stage Cancer, Multiple Sclerosis, and Noncancer, Nonneurological Disease From 4 PCCS Centers in Germany in 2013

Palliative Care, 2018
Context: During the last decade, numerous in-patient Palliative Care Consultation Service (PCCS) units were established throughout Germany. Objective: To provide an epidemiological overview on a whole year cohort of palliative patients in terms of ...
Birgit Basedow-Rajwich, Thomas Montag, Andreas Duckert, Christian Schulz, Gennadij Rajwich, Ingo Kleiter, Jürgen Koehler, Gabriele Lindena   +7 more
doaj   +1 more source

Non-pharmacological interventions to manage psychological distress in patients living with cancer: a systematic review

BMC Palliative Care, 2023
Background Psychological distress is common in patients with cancer; interfering with physical and psychological wellbeing, and hindering management of physical symptoms.
Carole A. Paley, Jason W. Boland, Martina Santarelli, Fliss E. M. Murtagh, Lucy Ziegler, Emma J. Chapman   +5 more
doaj   +1 more source

Palliative Care in Advanced Dementia

Frontiers in Psychiatry, 2020
Dementia syndrome is common and expected to increase significantly among older people and characterized by the loss of cognitive, psychological and physical functions.
Y. Eisenmann, H. Golla, Holger Schmidt, R. Voltz, K. Perrar   +4 more
semanticscholar   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source