Results 61 to 70 of about 178,160 (309)

Adaptation and multicentre validation of a patient-centred outcome scale for people severely ill with COVID (IPOS-COV)

Health and Quality of Life Outcomes, 2023
Background Patient-centred measures to capture symptoms and concerns have rarely been reported in severe COVID. We adapted and tested the measurement properties of the proxy version of the Integrated Palliative care Outcome Scale–IPOS-COV for severe ...
Mevhibe B. Hocaoglu, Fliss E. M. Murtagh, Catherine Walshe, Rachel L. Chambers, Matthew Maddocks, Katherine E. Sleeman, Adejoke O. Oluyase, Lesley Dunleavy, Andy Bradshaw, Sabrina Bajwah, Lorna K. Fraser, Nancy Preston, Irene J. Higginson, the CovPall study team   +13 more
doaj   +1 more source

The evolution of palliative care [PDF]

Patient Education and Counseling, 2000
An encounter with one patient in 1948 was the catalyst for the Hospice Movement. The challenge to undertake appropriate pain and symptom control together with experience in further listening to patients in the small number of homes especially planned for dying people, finally came together during the 1960s as the impetus for the first modern hospice ...
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Identification of Dutch hospital inpatients with possible palliative care needs: a nation-wide flash mob study

BMC Palliative Care
Background Identifying hospital inpatients who are approaching the end of life is essential for providing optimal palliative care. The study aims to determine the prevalence of hospital inpatients with a potentially limited life expectancy (
Annette WG van der Velden, Albert H de Heij, Marieke HJ van den Beuken, Evelien JM Kuip, Ginette M Hesselmann, Ellen JM de Nijs, Bregje AA Huisman, Astrid W Oosten, Anna KL Reyners, Pauline de Graeff   +9 more
doaj   +1 more source

“From good hearted community members we get volunteers” – an exploratory study of palliative care volunteers across Africa

BMC Palliative Care, 2020
Background Volunteers play a significant role in supporting hospice and palliative care in Africa, but little is known about the types of volunteers, their motivations and roles in service delivery.
Carolin Clara Loth, Eve Namisango, Richard Antony Powell, Katharina Henny Pabst, Mhoira Leng, Mohamed Hamada, Lukas Radbruch   +6 more
doaj   +1 more source

Conceptualising effective symptom management in palliative care: a novel model derived from qualitative data

BMC Palliative Care, 2022
Background Pain, breathlessness and fatigue are some of the most challenging symptoms to manage in patients with advanced disease. Specialist palliative care leads to better symptom management, but factors contributing to successful symptom management in
Emma J. Chapman, Simon Pini, Zoe Edwards, Yousuf Elmokhallalati, Fliss E. M. Murtagh, Michael I. Bennett   +5 more
doaj   +1 more source

Using the technology acceptance model to explore health provider and administrator perceptions of the usefulness and ease of using technology in palliative care

BMC Palliative Care, 2020
Background Studies have shown that telehealth applications in palliative care are feasible, can improve quality of care, and reduce costs but few studies have focused on user acceptance of current technology applications in palliative care.
Megan Nguyen, J. Fujioka, K. Wentlandt, Nike Onabajo, Ivy Wong, R. Bhatia, Onil Bhattacharyya, V. Stamenova   +7 more
semanticscholar   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source