Results 51 to 60 of about 173,441 (258)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Experiences of a Novel Integrated Service for Older Adults at Risk of Frailty: A Qualitative Study

Journal of Patient Experience, 2023
The UK has a significant and growing population of older adults with frailty and complex healthcare needs, necessitating innovative care solutions. This study aimed to explore patients’ and carers’ experiences of a novel integrated service that was set ...
Imogen Wilson MSc, Blessing O Ukoha-kalu PhD, Mabel Okoeki PhD, Joseph Clark PhD, Jason W Boland PhD, Sophie Pask MSc, Ugochinyere Nwulu MSc, Helene Elliott-Button PhD, Anna Folwell MBChB, Miriam J Johnson MD, Daniel Harman MBChB, Fliss EM Murtagh PhD   +11 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Multicomponent Interventions for Adults With Cancer Cachexia: A Systematic Review

Journal of Cachexia, Sarcopenia and Muscle
Background Cancer cachexia has substantial impacts on people's quality of life. There is no current gold standard treatment, but the complex pathophysiology of cachexia suggests that a multitargeted and individualised treatment approach is needed.
Megan Bowers, Carmine Petrasso, Amy McLuskie, Joanne Bayly, Barry J. A. Laird, Irene J. Higginson, Matthew Maddocks   +6 more
doaj   +1 more source

Mobile Palliative Care Consultation Service (PCCS): Overview of Hospice and Palliative Care Evaluation (HOPE) Data on In-Patients With End-Stage Cancer, Multiple Sclerosis, and Noncancer, Nonneurological Disease From 4 PCCS Centers in Germany in 2013

Palliative Care, 2018
Context: During the last decade, numerous in-patient Palliative Care Consultation Service (PCCS) units were established throughout Germany. Objective: To provide an epidemiological overview on a whole year cohort of palliative patients in terms of ...
Birgit Basedow-Rajwich, Thomas Montag, Andreas Duckert, Christian Schulz, Gennadij Rajwich, Ingo Kleiter, Jürgen Koehler, Gabriele Lindena   +7 more
doaj   +1 more source

Palliative care for people with substance use disorder and multiple problems: a qualitative study on experiences of patients and proxies

BMC Palliative Care, 2019
Background Systematic research into palliative care (PC) for people with substance use disorder (SUD) and multiple problems is scarce. The existing literature shows problems in the organizational structure of this care, e.g., lack of clear care pathways.
Anne Ebenau, Boukje Dijkstra, Chantal ter Huurne, Jeroen Hasselaar, Kris Vissers, Marieke Groot   +5 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Translation and cultural adaptation of the Integrated Palliative care Outcome Scale including cognitive interviewing with patients and staff

BMC Palliative Care, 2017
Background To expand our clinical and scientific knowledge about holistic outcomes within palliative care, there is a need for agreed-upon patient-reported outcome measures.
Ingela Beck, Ulrika Olsson Möller, Marlene Malmström, Anna Klarare, Henrik Samuelsson, Carina Lundh Hagelin, Birgit Rasmussen, Carl Johan Fürst   +7 more
doaj   +1 more source

Response to “The opinion of French pulmonologists and palliative care physicians on non-invasive ventilation during palliative sedation at end of life: a nationwide survey’’

BMC Palliative Care, 2023
We have several major concerns about this article [Guastella et al 2021]. Although it states that it is about palliative sedation, it is not. Rather, it is about the French Claeys Leonetti Law about Continuous Deep Sedation (CDS) at the end of life [Loi ...
Robert Twycross, Christina Faull, David Wenzel, David Oliver   +3 more
doaj   +1 more source