Results 51 to 60 of about 178,329 (260)

A National Quality Initiative to Improve Palliative Care Outcomes: Identifying Enabling Factors that Drive Quality Improvement

Palliative Medicine Reports
Background: The Palliative Care Outcomes Collaboration (PCOC), established in 2005 and funded by the Australian Government, is a national quality improvement initiative that integrates patient outcome measures into routine clinical practice.
Sabina Clapham, Katherine Clark, Kylie Draper, Fiorina Mastroianni, Jesse Rand, Lisa Redwood, David Currow   +6 more
doaj   +1 more source

Prognostic awareness and its association with health outcomes in the last year of life

Cancer Medicine, 2023
Background Little research has examined changes in prognostic awareness (PA) in the last year of life and the extent PA change was associated with anxiety, depression, and spiritual well‐being among metastatic cancer patients.
Semra Ozdemir, Isha Chaudhry, Sean Ng, Irene Teo, Chetna Malhotra, Eric Andrew Finkelstein, COMPASS Study Group   +6 more
doaj   +1 more source

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas, Jakob Q. Weiss, Kellee N. Parker, Cathy Lee‐Miller   +3 more
wiley   +1 more source

Translation and cultural adaptation of the Integrated Palliative care Outcome Scale including cognitive interviewing with patients and staff

BMC Palliative Care, 2017
Background To expand our clinical and scientific knowledge about holistic outcomes within palliative care, there is a need for agreed-upon patient-reported outcome measures.
Ingela Beck, Ulrika Olsson Möller, Marlene Malmström, Anna Klarare, Henrik Samuelsson, Carina Lundh Hagelin, Birgit Rasmussen, Carl Johan Fürst   +7 more
doaj   +1 more source

Experiences of a Novel Integrated Service for Older Adults at Risk of Frailty: A Qualitative Study

Journal of Patient Experience, 2023
The UK has a significant and growing population of older adults with frailty and complex healthcare needs, necessitating innovative care solutions. This study aimed to explore patients’ and carers’ experiences of a novel integrated service that was set ...
Imogen Wilson MSc, Blessing O Ukoha-kalu PhD, Mabel Okoeki PhD, Joseph Clark PhD, Jason W Boland PhD, Sophie Pask MSc, Ugochinyere Nwulu MSc, Helene Elliott-Button PhD, Anna Folwell MBChB, Miriam J Johnson MD, Daniel Harman MBChB, Fliss EM Murtagh PhD   +11 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Multicomponent Interventions for Adults With Cancer Cachexia: A Systematic Review

Journal of Cachexia, Sarcopenia and Muscle
Background Cancer cachexia has substantial impacts on people's quality of life. There is no current gold standard treatment, but the complex pathophysiology of cachexia suggests that a multitargeted and individualised treatment approach is needed.
Megan Bowers, Carmine Petrasso, Amy McLuskie, Joanne Bayly, Barry J. A. Laird, Irene J. Higginson, Matthew Maddocks   +6 more
doaj   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Machine learning model for prediction of palliative care phases in patients with advanced cancer: a retrospective study

BMC Palliative Care
Background Developing an accurate predictive model for palliative care phases is crucial for improving cancer patient management, enabling healthcare providers to identify those in need of specific care plans and streamlining decision-making process for ...
Junchen Guo, Yunyun Dai, Sishan Jiang, Junqingzhao Liu, Xianghua Xu, Yongyi Chen   +5 more
doaj   +1 more source