Results 81 to 90 of about 2,916,072 (249)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Heart failure in palliative care

Medycyna Paliatywna, 2016
In recent years, there has been increased interest in palliative care of patients with heart disease. It is associated with a large number of patients, a significant need for care, important end-stage infirmity in this group of patients, and a huge ...
Piotr Jakubów, Grzegorz Juszczyk, Tomasz Hirnle   +2 more
doaj  

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Primary palliative care competency framework for primary care and family physicians in India-Collaborative work by Indian Association of Palliative Care and Academy of Family Physicians of India

Journal of Family Medicine and Primary Care, 2019
The discrepancy in the demand for palliative care and distribution of specialist palliative care services will force patients to be eventually cared for by primary care/family physicians in the community.
Shrikant Atreya, Jenifer Jeba, Nikki Pease, Ann Thyle, Scott Murray, Alan Barnard, Dan Munday, Lulu Mathews, Mhoira Leng, Gayatri Palat, Alka Ganesh, Sulagna Chakraborty, Sahaya Anbarasi, Raman Kumar, Maryann Muckaden, Elizabeth Grant   +15 more
doaj   +1 more source

Exploring complexity in community palliative care: a practitioner based approach to research and development [PDF]

This thesis explores the complex discipline of community palliative care. Palliative patients suffer from a range of conditions, have complex, evolving clinical problems and receive care from a wide variety of health and social care professionals ...
Munday, Dan
core  

A strategy to advance the evidence base in palliative medicine: formation of a palliative care research cooperative group. [PDF]

, 2010
BACKGROUND: Palliative medicine has made rapid progress in establishing its scientific and clinical legitimacy, yet the evidence base to support clinical practice remains deficient in both the quantity and quality of published studies.
Portenoy, Russell K., Rocker, Graeme, Zafar, S Yousuf, Noreen M. Aziz, Cleeland, Charles S, Lloyd, Linda, Bull, Janet, Ritchie, Christine, Otis-Green, Shirley, Ko, Danielle N, Portenoy, Russell K, Diane Fairclough, Zafar, S. Yousuf, Hauser, Joshua, Morrison, R. Sean, R. Sean Morrison, Kutner, Jean S., Kutner, Jean S, Linda Lloyd, Currow, David C., Abernethy, Amy P., Janet Bull, Wheeler, Jane L, Currow, David Christopher, Danielle Ko, Christine Ritchie, Cleeland, Charles S., Charles S. Cleeland, Abernethy, Amy P, S. Yousuf Zafar, Steve Pantilat, Aziz, Noreen M, Wheeler, Jane L., Fairclough, Diane, Currow, David C, David C. Currow, Jane L. Wheeler, Laura Hanson, Graeme Rocker, Morrison, R Sean, Shirley Otis-Green, Pantilat, Steve, Basch, Ethan, Ko, Danielle, Russell K. Portenoy, Aziz, Noreen M., Amy P. Abernethy, Abernethy, Amy Pickar, Hanson, Laura, Ethan Basch, Joshua Hauser, Jean S. Kutner   +51 more
core   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

Decision-Making by Emergency Medicine Personnel in Prehospital Treatment of Patients Receiving Palliative Care: A Questionnaire, Comparative Cohort Study

Advances in Medical Education and Practice, 2021
Thidathit Prachanukool, Chaiyaporn Yuksen, Sirada Jintanavasan, Chetsadakon Jenpanitpong, Sorawich Watcharakitpaisan, Parama Kaninworapan, Konwachira Maijan Department of Emergency Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University ...
Prachanukool T, Yuksen C, Jintanavasan S, Jenpanitpong C, Watcharakitpaisan S, Kaninworapan P, Maijan K   +6 more
doaj  

Perceived Impacts and Predictors of Cannabis Products Used by Patients with Rheumatologic Conditions in Alberta, Canada: A Multivariable Analysis of Cross‐Sectional Survey Data

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among patients with rheumatologic conditions and their associations with patient factors, patient‐reported perceived side effects, and positive impacts.
Susan Zhang, Samuel A.J. Lowe, Frank Sun, Allyson Jones, Tarek Turk, Joanne Olson, Pauline Paul, Shelby Yamamoto, Linda Kolewaski, Elaine Yacyshyn, Cheryl A. Sadowski   +10 more
wiley   +1 more source