Results 61 to 70 of about 2,916,072 (249)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Prevalence of distressing symptoms in hospitalised patients on medical wards: A cross-sectional study

BMC Palliative Care, 2008
Background Many patients with advanced, serious, non-malignant disease belong to the population generally seen on medical wards. However, little research has been carried out on palliative care needs in this group. The aims of this study were to estimate
Sigurdardottir Katrin, Haugen Dagny
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Prevalence of patients with unmet palliative care needs in a University Emergency Department in Germany – a cross-sectional screening study

BMC Palliative Care
Background People with life-limiting diseases can benefit from early integration of palliative care, yet early identification of these patients is challenging.
Kristine Engeleit, Kambiz Afshar, Stephanie Stiel, Nils Schneider, Tanja Schleef, Torben Brod   +5 more
doaj   +1 more source

Providing Pediatric Palliative Care Education Using Problem-Based Learning

, 2018
BACKGROUND: The Institute of Medicine and the American Academy of Pediatrics has called for improvement in education and training of pediatricians in pediatric palliative care (PPC).
Rebecca Baker, Ruth O. Santizo, Priya Pinto, Pinto, Priya, Schechter, Miriam, Fausto, James, James Fausto, Baker, Rebecca, Santizo, Ruth O., Miriam Schechter, Cohen, Hillel, Pablo Joo, Hillel Cohen, Karen Moody, McHugh, Marlene, Marlene McHugh, Moody, Karen, Stephanie Deutsch, Deutsch, Stephanie, Joo, Pablo   +19 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Evaluation of Medical Students’ Knowledge on Palliative Care: A Single Institution Cross-sectional Study

Advances in Medical Education and Practice, 2022
Rafat Mohammed Mosalli,1,2 Ahmed Hafez Mousa,3 Asim Muhammed Alshanberi,3,4 Mohammed A Almatrafi2 1Department of Pediatrics, Batterjee Medical College, Jeddah, Saudi Arabia; 2Department of Pediatrics, Um Al-Qura University, Makkah, Saudi Arabia; 3College
Mosalli RM, Mousa AH, Alshanberi AM, Almatrafi MA   +3 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Palliative medicine physician Lyle Fettig reviews some themes to focus on for clinicians working in a pandemic. [PDF]

, 2020
I love the letter co-published by Pallimed and Geripal about COVID, and you should read that too. As an erstwhile (for now) Pallimed contributor, I thought I'd toss in my two cents with some additional thoughts/reflections based on week 1 of preparing ...
Fettig, Lyle Patrick
core   +1 more source