Results 51 to 60 of about 2,916,072 (249)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Palliative care in COPD: an unmet area for quality improvement
International Journal of COPD, 2015 Julia H Vermylen,1 Eytan Szmuilowicz,2 Ravi Kalhan3 1Department of Medicine, 2Section of Palliative Medicine, Department of Medicine, 3Asthma and COPD Program, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Vermylen JH, Szmuilowicz E, Kalhan R
doaj
Curing Diseases and Healing Suffering: Inspiration from Developments in Palliative Medicine
International Journal of Gerontology, 2008 Geriatrics and palliative medicine are medical specialties that share much in common: they are relatively recent disciplines, they deal with the elderly, and end-of-life issues are prominent.
Douglas T. Bridge
doaj +1 more source
BMC Palliative Care, 2022 Background Internal medicine residents are responsible for providing much of the direct care for palliative and terminally ill patients in teaching hospitals in the United Arab Emirates (UAE).
Halah Ibrahim, Thana Harhara
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Journal of Multidisciplinary Healthcare, 2019 Nga Yu Cheung, Anna Gorelik, Parag Mehta, Louis Mudannayake, Arundati Ramesh, Thayyllathil Bharathan, Gregory GoldenbergDepartment of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USABackground: With growing expense in ...
Cheung NY +6 more
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Measures of spiritual issues for palliative care patients: A literature review [PDF]
, 2008 Members of the EORTC Quality of Life Group are developing a standalone functional measure of spiritual wellbeing for palliative care patients, which will have both a clinical and a measurement application.
Vivat, B
core +4 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Improving palliative care for people with intellectual disabilities: Communication is key
, 2021 In this virtual special issue of Palliative Medicine, we bring together seven papers published in Palliative Medicine that highlight the importance of communication in the provision of palliative care for people with intellectual disabilities ...
Bloomer, Melissa J, Watson, Joanne
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source