Results 41 to 50 of about 150,427 (264)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Perception of palliative medicine by health care professionals at a teaching community hospital: what is the key to a “palliative attitude”?

Journal of Multidisciplinary Healthcare, 2019
Nga Yu Cheung, Anna Gorelik, Parag Mehta, Louis Mudannayake, Arundati Ramesh, Thayyllathil Bharathan, Gregory GoldenbergDepartment of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USABackground: With growing expense in ...
Cheung NY, Gorelik A, Mehta P, Mudannayake L, Ramesh A, Bharathan T, Goldenberg G   +6 more
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Prevalence of distressing symptoms in hospitalised patients on medical wards: A cross-sectional study

BMC Palliative Care, 2008
Background Many patients with advanced, serious, non-malignant disease belong to the population generally seen on medical wards. However, little research has been carried out on palliative care needs in this group. The aims of this study were to estimate
Sigurdardottir Katrin, Haugen Dagny
doaj   +1 more source

Palliative care in Malawi: a scoping review

BMC Palliative Care, 2023
Background Universal access to palliative care remains a distant goal in many low resource settings, despite the growing evidence of its benefits. The unmet need for palliative care is evident in Africa, but great strides in palliative care development ...
Natalie Palumbo, Alyssa Tilly, Eve Namisango, Christian Ntizimira, Lameck Thambo, Maria Chikasema, Gary Rodin   +6 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Evaluation of Medical Students’ Knowledge on Palliative Care: A Single Institution Cross-sectional Study

Advances in Medical Education and Practice, 2022
Rafat Mohammed Mosalli,1,2 Ahmed Hafez Mousa,3 Asim Muhammed Alshanberi,3,4 Mohammed A Almatrafi2 1Department of Pediatrics, Batterjee Medical College, Jeddah, Saudi Arabia; 2Department of Pediatrics, Um Al-Qura University, Makkah, Saudi Arabia; 3College
Mosalli RM, Mousa AH, Alshanberi AM, Almatrafi MA   +3 more
doaj  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Prevalence of patients with unmet palliative care needs in a University Emergency Department in Germany – a cross-sectional screening study

BMC Palliative Care
Background People with life-limiting diseases can benefit from early integration of palliative care, yet early identification of these patients is challenging.
Kristine Engeleit, Kambiz Afshar, Stephanie Stiel, Nils Schneider, Tanja Schleef, Torben Brod   +5 more
doaj   +1 more source