Results 71 to 80 of about 2,916,072 (249)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Co-operation of the Intensive Care Unit of the University Hospital in Bialystok with Palliative Medicine Centers in the years 2011–2016

Medycyna Paliatywna, 2017
Introduction: The principles of palliative medicine are interdisciplinary. In the Intensive Care Unit (ICU), for patients with irreversible disease, with a negative prognosis for improvement in health, in futile therapy, palliative care are provided ...
Urszula Kościuczuk, Piotr Jakubów, Juliusz Kosel, Andrzej Siemiątkowski, Paweł Kosierkiewicz   +4 more
doaj  

Evaluating educational initiatives to improve palliative care for people with dementia: A narrative review. [PDF]

, 2014
Dementia accounts for one in three deaths among people aged 65 and over, but end-of-life care for people with dementia is often sub-optimal. Palliative care for people with dementia poses particular challenges to those providing services, and current ...
Baishnab, E, Warner, Alex, Manthorpe, Jill; id_orcid, Davies, N, Manthorpe, J, Raymond, M, Warner, A, Raymond, Mareeni, Baishnab, Elora, Iliffe, S, Davies, Nathan, Iliffe, Steve   +11 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Trends and challenges in research on integrative health practices and pediatric palliative care: a bibliometric approach

Frontiers in Pediatrics
BackgroundApproximately 21 million children and adolescents worldwide require palliative care annually. Pediatric palliative care (PPC) seeks to improve the quality of life of patients, families and caregivers through a holistic and multidisciplinary ...
Aline Maria de Oliveira Rocha, Aline Maria de Oliveira Rocha, Aline Maria de Oliveira Rocha, Flávia H. Santos, João Roberto Bissoto, Claudio Arnaldo Len, Simone Brasil de Oliveira Iglesias   +6 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

The palliative care day centre – a missing link of palliative care in the healthcare system

Medycyna Paliatywna
The Standards Committee of the Polish Society of Palliative Medicine has developed an organisational model of the Palliative and Supportive Care Day Centre as part of its works on organisational standards in palliative care.
Aleksandra D. Ciałkowska-Rysz, Tomasz Dzierżanowski, Artur Pakosz, Anna Zasowska-Nowak   +3 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Clinical Hypnosis, Relaxation and Mindfulness in Pain Therapy and Palliative Care: Techniques for Improving the Patient's Physical and Psychological Well-being

, 2015
Clinical hypnosis in Pain Therapy and Palliative Care, involves highly focused attention and an enhanced ability to modulate perceptions. This workshop explores the fields of Clinical Hypnosis and Self-Hypnosis as applied to the therapy of acute and ...
Brugnoli, Maria Paola
core