Results 111 to 120 of about 1,639,886 (255)

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Impact of Palliative Gastrojejunostomy Type on Survival in Patients with Unresectable Pancreatic Head Cancer: A Retrospective Analysis

Biomedicines
Gastrojejunostomy (GJ) is used as a palliative procedure in patients with inoperable pancreatic head cancer. While its primary goal is to relieve obstruction, clinical observations suggest the type of reconstruction may influence survival.
Oliwia Grząsiak-Kraj, Tomasz Kraj, Janusz Strzelczyk   +2 more
doaj   +1 more source

An evaluation of palliative care education in the specialist training programme in family medicine [PDF]

, 2010
Aim: The study aimed to evaluate the teaching in palliative care (PC) provided during the Specialist Training Programme in Family Medicine (STPFM) in Malta.
Mallia, Pierre, Abela, Jurgen C.
core  

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

An evaluation of palliative care in rural Tanzania where availability of oral morphine is intermittent or absent [PDF]

, 2011
Includes bibliographical details.In Tanzania, palliative care is relatively new, and faces the common challenges of access to services, crucial medications, and education.
Hartwig, Kristopher
core   +1 more source

Surgical management of small bowel metastasis from esophageal squamous cell carcinoma: a case report and literature review

Frontiers in Surgery
BackgroundSmall bowel metastasis from esophageal squamous cell carcinoma (ESCC) is an exceedingly rare event, typically diagnosed only during emergency surgery for obstruction or perforation.
Qiujin Huang, Xiang Huifei, Liu Qiaoyun
doaj   +1 more source

The rationality of resectional surgery and palliative interventions in the management of patients with gallbladder cancer

, 2015
The aim of the present study was to evaluate in a retrospective manner, the survival period and survival rate according to stages and groups after R0, R1, R2 resections and palliative interventions.
Karaman, Kerem
core  

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Value of palliative surgery in perihilar cholangiocarcinoma. [PDF]

Langenbecks Arch Surg, 2023
Dondorf F, Rohland O, Deeb AA, Ardelt M, Settmacher U, Rauchfuss F.   +5 more
europepmc   +1 more source