Results 31 to 40 of about 1,639,886 (255)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A case report of severe diarrhea due to cytomegalovirus infection after living donor liver transplantation: successful treatment with butyrate-producing bacteria, immunosuppressive adjustments, and anti-cytomegalovirus therapy

Fujita Medical Journal
Purpose: In recent years, the benefits of probiotics for perioperative management have been recognized, and butyrate-producing bacteria are attracting attention as new beneficial intestinal bacteria.
Masanobu Usui, Norimasa Tsuzuki, Miyo Murai, Akihiro Ito, Akihiko Futamura   +4 more
doaj   +1 more source

Palliative Gastrointestinal Surgery in Patients With Advanced Peritoneal Carcinomatosis: Clinical Experience and Development of a Predictive Model for Surgical Outcomes

Frontiers in Oncology, 2022
BackgroundPalliative gastrointestinal (GI) surgery potentially relieves distressing symptoms arising from intestinal obstruction (IO) in patients with advanced peritoneal carcinomatosis (PC).
Jolene Si Min Wong, Jolene Si Min Wong, Jolene Si Min Wong, Jolene Si Min Wong, Sze Min Lek, Daniel Yan Zheng Lim, Claramae Shulyn Chia, Claramae Shulyn Chia, Claramae Shulyn Chia, Claramae Shulyn Chia, Grace Hwei Ching Tan, Grace Hwei Ching Tan, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Melissa Ching Ching Teo, Melissa Ching Ching Teo, Melissa Ching Ching Teo, Melissa Ching Ching Teo   +21 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Palliative Surgery for Cancer in Southwest Nigeria

The Annals of African Surgery, 2019
Background: Most patients with cancer in the low-income environment present late, when the chances of cure are remote. Palliative care which includes surgery is needed to improve quality of life and minimize suffering and emotional disturbances ...
Babatunde Ayoade, Abimbola Oyelekan, Oluwabunmi Fatungase, Chigbundu Nwokoro, Babatunde Salami, Adeleke Adekoya   +5 more
doaj  

Investigating the nutritional status characteristics of terminal cancer patients by the type of cancer

Fujita Medical Journal
Objective: Patients with terminal cancer experience malnutrition due to cachexia and other problems associated with the disease’s progression. Particularly, patients with gastrointestinal cancers often experience malnutrition because of gastrointestinal ...
Norimasa Tsuzuki, Masanobu Usui, Akihiko Futamura, Miyo Murai, Akihiro Ito   +4 more
doaj   +1 more source

Palliative care services in Australia 2014 [PDF]

, 2014
This is the third in a planned series of annual reports providing a detailed picture of the national response to the palliative care needs of Australians. Summary This report on Australian palliative care services is the third in this series.

core  

Surgery and palliative care: Is there common ground or simply a clash of cultures?

, 2014
© 2014 Springer-Verlag Berlin Heidelberg. All rights reserved. The goal of clinical medicine is to improve or maintain the best possible health and well-being.
Cartmill, J, John Cartmill, Currow, DC, David C. Currow   +3 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Challenges, care gaps, and coping mechanisms in patients with advanced cancer and their caregivers following palliative gastrointestinal surgery

Palliative Care and Social Practice
Background: Palliative gastrointestinal surgery improves symptoms and health-related quality of life in patients who present with complications from advanced cancer.
Xiaofan Zhong, Wei Jing Fong, Darryl Juan, Mingzhe Cai, Jane Chin Jin Seo, Johnny Chin-Ann Ong, Claramae Chia, Jolene Si Min Wong, Sungwon Yoon   +8 more
doaj   +1 more source