Results 41 to 50 of about 112,157 (262)

Guidelines for palliative surgery of cholangiocarcinoma [PDF]

HPB, 2008
The aims of the guidelines are to help assess the evidence for palliation surgery in patients with cholangiocarcinoma (CCA). The guidelines are classified in accordance with the location of the primary lesion, i.e. intrahepatic, hilar, and distal. They are based on comprehensive literature surveys, including results from randomized controlled trials ...
Witzigmann, H., Lang, H., Lauer, H.
openaire   +2 more sources

Phase Angle as an Early Functional Biomarker of Cancer‐Related Fatigue in Pediatric Oncology: A Prospective Longitudinal Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric cancer remains a leading cause of morbidity and mortality worldwide, particularly in low‐and middle‐income countries. Cancer treatment may impair nutritional status, alter body composition, and exacerbate cancer‐related fatigue (CRF).
Luís Carlos Lopes‐Junior, Luiz Claudio Barreto Silva Neto, Fabiano Kenji Haraguchi, Letícia Batista de Azevedo, Marcelo Brenner Nascimento Carlini, Raphael Manhães Pessanha, Mariana Rabello Laignier, Wesley Rocha Grippa, Tania Mara Lopes Bitti Bortolini, Gláucia Zouain‐Figueiredo, Regina Aparecida Garcia de Lima, Liliana Vasquez   +11 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Natural Language Processing for serious illness communications in palliative surgical oncology

Annals, Academy of Medicine, Singapore
Approximately one-fifth of surgeries performed at major cancer centres worldwide are palliative in nature, and one-third of advanced cancer patients receive surgery during their last year of life.1,2 Serious illness communication (SIC) is an essential ...
Louis Choon Kit Wong, Nicholas Brian Shannon, Qingyuan Zhuang, Hairil Rizal Abdullah, Wei Jing Fong, Claramae Shulyn Chia, Jolene Si Min Wong   +6 more
doaj   +1 more source

Bone metastases in breast cancer: Frequency, metastatic pattern and non-systemic locoregional therapy

Journal of Bone Oncology, 2014
Background: The study evaluates the frequency of and indications for bone-metastases (BM)-related surgery and/or radiotherapy in the palliative breast cancer (BC) situation and analyzes in which phase of the palliative disease course surgery and/or ...
Kirsten Steinauer, Dorothy Jane Huang, Serenella Eppenberger-Castori, Esther Amann, Uwe Güth   +4 more
doaj   +1 more source

Retrospective Clinical Analysis of Epilepsy Treatment for Children with Drug-Resistant Epilepsy (A Single-Center Experience)

Brain Sciences, 2022
Objectives: This retrospective cohort study investigated the clinical characteristics and seizure outcomes of patients aged 1–14 years with drug-resistant epilepsy (DRE) who were treated by different typologies of therapy.
Changqing Liu, Yue Hu, Jian Zhou, Yuguang Guan, Mengyang Wang, Xueling Qi, Xiongfei Wang, Huawei Zhang, Aihemaitiniyazi Adilijiang, Tiemin Li, Guoming Luan   +10 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Usefulness of cell-free and concentrated pleural effusion reinfusion therapy in terminal cancer patients

Fujita Medical Journal
Objective: Patients with advanced or recurrent cancer often suffer from excessive fluid retention, which substantially affects their quality of life. There are no detailed reports regarding cell-free and concentrated pleural effusion reinfusion therapy ...
Hiroyuki Fujisaki, Masanobu Usui, Akihiro Ito, Miyo Murai, Norimasa Tsuzuki, Akihiko Futamura, Kazuki Imai, Yoshinori Itani   +7 more
doaj   +1 more source

Palliative Gastrointestinal Surgery in Patients With Advanced Peritoneal Carcinomatosis: Clinical Experience and Development of a Predictive Model for Surgical Outcomes

Frontiers in Oncology, 2022
BackgroundPalliative gastrointestinal (GI) surgery potentially relieves distressing symptoms arising from intestinal obstruction (IO) in patients with advanced peritoneal carcinomatosis (PC).
Jolene Si Min Wong, Jolene Si Min Wong, Jolene Si Min Wong, Jolene Si Min Wong, Sze Min Lek, Daniel Yan Zheng Lim, Claramae Shulyn Chia, Claramae Shulyn Chia, Claramae Shulyn Chia, Claramae Shulyn Chia, Grace Hwei Ching Tan, Grace Hwei Ching Tan, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Chin-Ann Johnny Ong, Melissa Ching Ching Teo, Melissa Ching Ching Teo, Melissa Ching Ching Teo, Melissa Ching Ching Teo   +21 more
doaj   +1 more source

Palliative Care in Surgery [PDF]

Annals of Surgery, 2017
To describe the existing science of palliative care in surgery within three priority areas and expose specific gaps within the field.Given the acute and often life-limiting nature of surgical illness, as well as the potential for treatment to induce further suffering, surgical patients have considerable palliative care needs.
Elizabeth J, Lilley, Zara, Cooper, Margaret L, Schwarze, Anne C, Mosenthal   +3 more
openaire   +4 more sources