Results 151 to 160 of about 32,016,499 (171)
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Targeted Oncology, 2023
Palmitoyl-protein thioesterase-1 (PPT1) is a clinical stage druggable target for inhibiting autophagy in cancer.We aimed to determine the cellular and molecular activity of targeting PPT1 using ezurpimtrostat, in combination with an anti-PD-1 antibody.In this study we used a transgenic immunocompetent mouse model of hepatocellular carcinoma.Herein, we ...
Eloïne Bestion +8 more
openaire +2 more sources
Palmitoyl-protein thioesterase-1 (PPT1) is a clinical stage druggable target for inhibiting autophagy in cancer.We aimed to determine the cellular and molecular activity of targeting PPT1 using ezurpimtrostat, in combination with an anti-PD-1 antibody.In this study we used a transgenic immunocompetent mouse model of hepatocellular carcinoma.Herein, we ...
Eloïne Bestion +8 more
openaire +2 more sources
Experimental Cell Research, 2006
Infantile neuronal ceroid lipofuscinosis (INCL) is a severe neurodegenerative disorder of the childhood caused by mutations in the gene encoding palmitoyl protein thioesterase 1 (PPT1). PPT1 localizes to late endosomes/lysosomes of non-neuronal cells and in neurons also to presynaptic areas.
Kaisu Luiro +2 more
exaly +3 more sources
Infantile neuronal ceroid lipofuscinosis (INCL) is a severe neurodegenerative disorder of the childhood caused by mutations in the gene encoding palmitoyl protein thioesterase 1 (PPT1). PPT1 localizes to late endosomes/lysosomes of non-neuronal cells and in neurons also to presynaptic areas.
Kaisu Luiro +2 more
exaly +3 more sources
Molecular Reproduction and Development, 2013
SUMMARYMale obesity may lead to declines in testosterone levels, reproductive hormonal profile, and semen quantity. To assess the effects of obesity on spermatogenesis, Sprague–Dawley rats fed a high‐fat diet served as a model of induced obesity. The litter sizes for females mated to obese males were significantly lower as compared to females mated ...
Yue, Liu +6 more
openaire +2 more sources
SUMMARYMale obesity may lead to declines in testosterone levels, reproductive hormonal profile, and semen quantity. To assess the effects of obesity on spermatogenesis, Sprague–Dawley rats fed a high‐fat diet served as a model of induced obesity. The litter sizes for females mated to obese males were significantly lower as compared to females mated ...
Yue, Liu +6 more
openaire +2 more sources
2022
The Neuronal Ceroid Lipofuscinoses (NCL) are a group of progressive neurodegenerative disorders, associated with 14 Ceroid Lipofuscinosis Neuronal genes (CLN1-14). The mutations in the Palmitoyl-Protein Thioesterase 1 (PPT1) protein serve as one of the major reasons for the causative of NCL.
D, Thirumal Kumar +3 more
openaire +2 more sources
The Neuronal Ceroid Lipofuscinoses (NCL) are a group of progressive neurodegenerative disorders, associated with 14 Ceroid Lipofuscinosis Neuronal genes (CLN1-14). The mutations in the Palmitoyl-Protein Thioesterase 1 (PPT1) protein serve as one of the major reasons for the causative of NCL.
D, Thirumal Kumar +3 more
openaire +2 more sources
Palmitoyl Protein Thioesterase 1 Protects Against Apoptosis Mediated by Ras—Akt—Caspase Pathway in Neuroblastoma Cells [PDF]
Journal of Neurochemistry, 2000 Abstract: Palmitoyl protein thioesterase (PPT) 1 is an enzyme involved in deacylation of palmitoylated proteins. A deficiency in PPT1 results in a genetic disease, infantile neuronal ceroid lipofuscinosis, associated with massive death of cortical neurons.
S, Cho, G, Dawson
exaly +3 more sources
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Palmitoyl-protein thioesterase 1 (PPT1), a key depalmitoylating enzyme, modulates substrate protein function and lipid metabolism through enzymatic thioester bond hydrolysis of the palmitoyl-thioester bond. While PPT1 may regulate lipid metabolism through dynamic palmitoylation, its fundamental regulatory pathways require further elucidation.
Hequn, Li +6 more
openaire +2 more sources
Palmitoyl-protein thioesterase 1 (PPT1), a key depalmitoylating enzyme, modulates substrate protein function and lipid metabolism through enzymatic thioester bond hydrolysis of the palmitoyl-thioester bond. While PPT1 may regulate lipid metabolism through dynamic palmitoylation, its fundamental regulatory pathways require further elucidation.
Hequn, Li +6 more
openaire +2 more sources
EFFECT OF ORLISTAT ON TESTICULAR PALMITOYL PROTEIN THIOESTERASE 1 AND SEMENOGRAM IN OBESE RATS
ALEXMED ePostersAli Fouad Elariny +4 more
openaire +1 more source
Developmental expression of palmitoyl protein thioesterase in normal mice
Developmental Brain Research, 1999Hannah Mitchison +2 more
exaly
A Rapid Fluorogenic Palmitoyl-Protein Thioesterase Assay: Pre- and Postnatal Diagnosis of INCL
Molecular Genetics and Metabolism, 1999S L Vanhanen +2 more
exaly