Results 21 to 30 of about 32,016,499 (171)

Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction

Neurobiology of Disease, 2007
Infantile neuronal ceroid lipofuscinosis (INCL) is a severe neurodegenerative disorder of children, characterized by selective death of neocortical neurons.
Laura Ahtiainen, Julia Kolikova, Aino-Liisa Mutka, Kaisu Luiro, Massimiliano Gentile, Elina Ikonen, Leonard Khiroug, Anu Jalanko, Outi Kopra   +8 more
doaj   +3 more sources

Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells.

Journal of Proteomics, 2015
: Neuronal ceroid lipofuscinoses (NCL) are a group of inherited progressive childhood disorders, characterized by early accumulation of autofluorescent storage material in lysosomes of neurons or other cells. Clinical symptoms of NCL include: progressive
Scifo E., Baumann M. H., Soliymani R., Dębski J., Dadlez M., Gingras A. C., PEZZINI, Francesco, BIANCHI, MARZIA, Tyynelä J., Dapkunas A., Szwajda A., Uusi Rauva K., Jalanko A., SIMONATI, Alessandro, Lalowski M.   +14 more
core   +4 more sources

Binding of hydroxychloroquine and chloroquine dimers to palmitoyl-protein thioesterase 1 (PPT1) and its glycosylated forms: a computational approach.

Journal of Biomolecular Structure and Dynamics, 2021
International audienceThe lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1) removes thioester-linked fatty acid groups from membrane-bound proteins to facilitate their proteolysis.
Vergoten, Gerard, Bailly, Christian
core   +4 more sources

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science
PIK3CA mutations drive benign adipose overgrowth in facial infiltrating lipomatosis (FIL), but the downstream molecular mechanisms remain incompletely understood.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
doaj   +2 more sources

Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia. [PDF]

Metab Brain Dis, 2017
Infantile CLN1 disease, also known as infantile neuronal ceroid lipofuscinosis, is a fatal childhood neurodegenerative disorder caused by mutations in the CLN1 gene. CLN1 encodes a soluble lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1), and it is still unclear why neurons are selectively vulnerable to the loss of PPT1 enzyme activity in ...
Meyer M, Kovács AD, Pearce DA.
europepmc   +4 more sources

Erratum to “Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma” [PDF]

Research
Tianlong Huang, Yifan Chen, Qiangqiang Zhao, Xin Wu, Hongxing Li, Xin Luo, Yang Su, Shengqun Zhang, Pan Liu, Ning Tang   +9 more
doaj   +2 more sources

Genetic modifiers of Drosophila palmitoyl-protein thioesterase 1-induced degeneration. [PDF]

Genetics, 2007
AbstractInfantile neuronal ceroid lipofuscinosis (INCL) is a pediatric neurodegenerative disease caused by mutations in the human CLN1 gene. CLN1 encodes palmitoyl–protein thioesterase 1 (PPT1), suggesting an important role for the regulation of palmitoylation in normal neuronal function.
Buff H, Smith AC, Korey CA.
europepmc   +4 more sources

Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses in Drosophila larvae. [PDF]

Fly (Austin), 2013
Infantile-onset neuronal ceroid lipofuscinosis (INCL) is a severe pediatric neurodegenerative disorder produced by mutations in the gene encoding palmitoyl-protein thioesterase 1 (Ppt1). This enzyme is responsible for the removal of a palmitate group from its substrate proteins, which may include presynaptic proteins like SNAP-25, cysteine string ...
Aby E, Gumps K, Roth A, Sigmon S, Jenkins SE, Kim JJ, Kramer NJ, Parfitt KD, Korey CA.   +8 more
europepmc   +4 more sources

Enzymatic activity of palmitoyl-protein thioesterase-1 in serum from schizophrenia significantly associates with schizophrenia diagnosis scales. [PDF]

J Cell Mol Med, 2019
AbstractGenome‐wide association studies have confirmed that schizophrenia is an inheritable multiple‐gene mental disorder. Longitudinal studies about depression, first episode psychosis (FEP) and acute psychotic relapse have mostly searched for brain imaging biomarkers and inflammatory markers from the blood.
Wu Y, Zhang Q, Qi Y, Gao J, Li W, Lv L, Chen G, Zhang Z, Yue X, Peng S.   +9 more
europepmc   +4 more sources

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source