Results 71 to 80 of about 823,779 (195)

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

Advanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen, Yan Zhang, Pei Wang, Jiamin Ma, Xinru Zhao, Yi Li, Zhenghao Deng, Xueqing Meng, Jiali Zhu, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source

A brief overview on early events of Xa21 mediated pattern triggered immunity [PDF]

, 2019
In plant associated pattern-triggered immunity (PTI), pattern-recognition receptors (PRRs) play crucial role in the mechanism of first line of defense against pathogenic invasion.
Abu Naser, M., Hamdan, Salehhuddin, Mubassir, M. H. M., Abdul Wahab, Mohd. Firdaus   +3 more
core   +1 more source

Fully Integrated Wearable Ultrasound System for Continuous Promotion of Wound Healing

Advanced Science, EarlyView.
A wearable ultrasound system integrating a drug‐loaded patch and a miniaturized driving circuit is presented to achieve noninvasive, on‐demand stimulation, enabling programmable antibacterial activity, inflammation modulation, and accelerated wound closure through enhanced cell migration and collagen remodeling.
Faxing Zou, Yansen Wang, Yong Luo, Wenxuan Zhuang, Mingyu Zhu, Min Long, Qingzhou Liu, Tailin Xu   +7 more
wiley   +1 more source

Mitochondrial Protein MjEF‐Tu is Secreted into Host Plants by Nematodes Eliciting Immune Signaling and Resistance

Advanced Science
Little is known about plant‐parasitic animal‐derived pathogen‐associated molecular pattern (PAMP)/ pattern‐recognition receptor (PRR) pairs. Additionally, mitochondrial proteins have not previously been reported to be secreted into hosts by pathogens ...
Borong Lin, Shaozhen Huang, Zhiwen Li, Qiuling Huang, Handa Song, Tianyi Fang, Jinling Liao, Godelieve Gheysen, Kan Zhuo   +8 more
doaj   +1 more source

The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants [PDF]

, 2015
In pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI), plant cell surface receptors sense potential microbial pathogens by recognizing elicitors called PAMPs.
Heese, Antje, Li, Jia, Jones, Alexandra, He, Kai, Hann, Dagmar R, Peck, Scott C, Rathjen, John, Schroeder, Julian I, Gimenez-Ibanez, Selena   +8 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Quantitative phosphoproteomic analysis reveals common regulatory mechanisms between effector- and PAMP-triggered immunity in plants [PDF]

, 2018
Plant immunity consists of two arms: pathogen‐associated molecular pattern (PAMP)‐triggered immunity (PTI), induced by surface‐localized receptors, and effector‐triggered immunity (ETI), induced by intracellular receptors.
Shirasu, Ken, Sklenar, Jan; https://orcid.org/, Antonio Molina, Torres, Miguel-Angel; https://orcid.org/, Thomas W. H. Liebrand, Coaker, Gitta; https://orcid.org/, Derbyshire, Paul, Menke, Frank, Kadota, Yasuhiro; https://orcid.org/, Yasuhiro Kadota, Zipfel, Cyril, Coaker, Gitta, Menke, Frank L H; https://orcid.org/, Miguel‐Angel Torres, Liebrand, Thomas W H; https://orcid.org/, Frank L. H. Menke, Gitta Coaker, Ken Shirasu, Goto, Yukihisa, Sklenar, Jan, Menke, Franciscus, Liebrand, Thomas WH, Cyril Zipfel, Kadota, Yasuhiro, Liebrand, Thomas W. H., Torres, Miguel Ángel, Goto, Yukihisa; https://orcid.org/, Zipfel, Cyril; https://orcid.org/, Torres, Miguel-Angel, Molina, Antonio, Derbyshire, Paul; https://orcid.org/, Yukihisa Goto, Shirasu, Ken; https://orcid.org/, Liebrand, Thomas, Paul Derbyshire, Molina, Antonio; https://orcid.org/, Menke, Frank LH, Torres, Miguel‐Angel, Jan Sklenar, Menke, Frank L. H.   +39 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

AvrBsT acetylates Arabidopsis ACIP1, a protein that associates with microtubules and is required for immunity.

PLoS Pathogens, 2014
Bacterial pathogens of plant and animals share a homologous group of virulence factors, referred to as the YopJ effector family, which are translocated by the type III secretion (T3S) system into host cells during infection.
Mi Sun Cheong, Angela Kirik, Jung-Gun Kim, Kenneth Frame, Viktor Kirik, Mary Beth Mudgett   +5 more
doaj   +1 more source

Signalling of Arabidopsis thaliana response to Pieris brassicae eggs shares similarities with PAMP-triggered immunity [PDF]

, 2017
Insect egg deposition activates plant defence, but very little is known about signalling events that control this response. In Arabidopsis thaliana, oviposition by Pieris brassicae triggers salicylic acid (SA) accumulation and induces the expression of ...
Gouhier-Darimont, Caroline, Reymond, Philippe, Schmiesing, André, Lassueur, Steve, Bonnet, Christelle   +4 more
core