Results 121 to 130 of about 31,089 (264)

Intranasal Administration of Isoeugenol Improves Memory Deficits in APP/PS1 Old Mice—A Role Beyond Nrf2 Activation?

open access: yesThe FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Inactivation of the Nrf2/Are pathway in AD leads to decreased antioxidant and anti‐inflammatory response and to the accumulation of beta‐amyloid (Aβ) plaques, resulting in cognitive failure. Treatment with Isoeugenol activates Nrf2, reversing these outcomes by promoting antioxidant response in neuronal cells (N2a) and by increasing the anti ...
Ana Silva   +14 more
wiley   +1 more source

From armadillos to sloths: Patterns and variations in xenarthran coronary anatomy

open access: yesThe Anatomical Record, Volume 309, Issue 8, Page 2199-2220, August 2026.
Abstract Species of the superorder Xenarthra play a vital ecological role in the Neotropics. Despite their evolutionary significance, anatomical studies on their coronary circulation remain scarce. This study investigated the coronary anatomy of 82 hearts from nine Xenarthra species across the Dasypodidae, Myrmecophagidae, and Bradypodidae.
Wilson Viotto‐Souza   +5 more
wiley   +1 more source

Evaluation of Uliginosin B as a Modulator of the Ras Pathway: In Vivo Evidence From Caenorhabditis elegans and In Silico Insights

open access: yesChemistry &Biodiversity, Volume 23, Issue 8, August 2026.
This study performs in vivo and in silico assays with uliginosin B, targeting its activity in the Ras signaling pathway, demonstrating a possible allosteric interaction with the HRAS (human) and LET‐60 (nematode) proteins, and a decrease in the overexpression of the let‐60 gene in the nematode C. elegans.
Maria Eduarda O. De Souza   +9 more
wiley   +1 more source

ARIA‐EAACI 2025: Person‐Centred, Digitally Enabled and Artificial Intelligence‐Assisted Change Management in Airway Diseases

open access: yesClinical and Translational Allergy, Volume 16, Issue 8, August 2026.
ABSTRACT Allergic Rhinitis and its Impact on Asthma (ARIA) was, up until 2017, a guideline using the best evidence (Grading of Recommendations, Assessment, Development and Evaluation, GRADE) and developed as a change management strategy. A second change management strategy—in collaboration with the European Academy of Allergy and Clinical Immunology ...
Jean Bousquet   +155 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

open access: yesDrug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal   +10 more
wiley   +1 more source

Redescripción de la obrera de Myrmelachista gallicola (Hymenoptera: Formicidae) y primera cita para la provincia de La Pampa (Argentina) Redescription of the worker of Myrmelachista gallicola (Hymenoptera: Formicidae) and first record from La Pampa (Argentina)

open access: yesRevista de la Sociedad Entomológica Argentina, 2006
Se redescribe la obrera de Myrmelachista gallicola Mayr y se cita por primera vez para la provincia de La Pampa (Argentina). El material estudiado está compuesto por obreras y fue recolectado sobre Prosopis caldenia Burkart (Fabaceae), dentro de las ...
Estela M. Quirán, Juan J. Martínez
doaj  

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

open access: yesDrug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin   +11 more
wiley   +1 more source

Analysis of Climate Variability of Homogeneous Regions of Rainfall Anomalies in Southeast South America (SESA)

open access: yesInternational Journal of Climatology, Volume 46, Issue 10, August 2026.
We studied rainfall variability and cyclicity in six Homogeneous Regions of Rainfall Anomalies (HRRA) in Southeast South America (SESA) from 1961 to 2020 to understand the occurrence of droughts and above‐average rainfall. We use a continental analysis scale, focusing on seasonal, interannual, and interdecadal cycles, and their association with modes ...
Tainã Costa Peres   +4 more
wiley   +1 more source

DNA barcoding for identification of species involved in wildlife strikes at Brazilian airports

open access: yesThe Journal of Wildlife Management, Volume 90, Issue 6, August 2026.
A collaborative network of 42 Brazilian airports applied DNA barcoding to identify 80 species involved in wildlife strikes. Among them, 32 species (17 birds and 15 bats) were not currently available in Brazil's wildlife strike reporting database, underscoring the value of molecular tools for strengthening wildlife strike monitoring. Abstract This study
Andre Akira Gonzaga Yoshikawa   +11 more
wiley   +1 more source

Uptake and Transport of Monotropein and Monotropein Esters in a Caco‐2/HT29‐MTX‐E12 Co‐Culture Model

open access: yesMolecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.
Monotropein and its naturally occurring ester derivatives (monotropein‐10‐coumarate and monotropein‐10‐cinnamate) from Gaultheria spp. berries exhibit limited intestinal permeability in a validated Caco‐2:HT29‐MTX‐E12 co‐culture model. Absorption occurs predominantly via passive diffusion, with partial SGLT1‐ and OATP‐mediated uptake contribution for ...
Christian Zielinski   +7 more
wiley   +1 more source

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