Results 121 to 130 of about 31,089 (264)
Intranasal Administration of Isoeugenol Improves Memory Deficits in APP/PS1 Old Mice—A Role Beyond Nrf2 Activation?
The FASEB Journal, Volume 40, Issue 15, 15 August 2026.Inactivation of the Nrf2/Are pathway in AD leads to decreased antioxidant and anti‐inflammatory response and to the accumulation of beta‐amyloid (Aβ) plaques, resulting in cognitive failure. Treatment with Isoeugenol activates Nrf2, reversing these outcomes by promoting antioxidant response in neuronal cells (N2a) and by increasing the anti ...Ana Silva, Sónia Silva, Jéssica Macedo, Patrícia Moreira, Diana Baptista, Joana Bicker, Ana Fortuna, Joana Liberal, Beatriz Rodrigues, Rosa Resende, Inês Vitorino, Armanda E. Santos, Bruno Miguel Neves, Cláudia Pereira, Maria Teresa Cruz +14 morewiley +1 more sourceFrom armadillos to sloths: Patterns and variations in xenarthran coronary anatomy
The Anatomical Record, Volume 309, Issue 8, Page 2199-2220, August 2026.Abstract
Species of the superorder Xenarthra play a vital ecological role in the Neotropics. Despite their evolutionary significance, anatomical studies on their coronary circulation remain scarce. This study investigated the coronary anatomy of 82 hearts from nine Xenarthra species across the Dasypodidae, Myrmecophagidae, and Bradypodidae.Wilson Viotto‐Souza, André Luiz Quagliatto Santos, Marcelo Abidu‐Figueiredo, Thaís Aparecida Silva, Rodrigo Ananias Barreiros Silva, Paulo de Souza‐Junior +5 morewiley +1 more sourceEvaluation of Uliginosin B as a Modulator of the Ras Pathway: In Vivo Evidence From Caenorhabditis elegans and In Silico Insights
Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.This study performs in vivo and in silico assays with uliginosin B, targeting its activity in the Ras signaling pathway, demonstrating a possible allosteric interaction with the HRAS (human) and LET‐60 (nematode) proteins, and a decrease in the overexpression of the let‐60 gene in the nematode C. elegans.Maria Eduarda O. De Souza, Flávia Suelen De O. Pereira, Daniela Teixeira Rodrigues, Helder Dias Costa, Tarsila Dantas Da Rosa, Camila Machado Pires da Silva, Gilsane von Poser, Stela M. K. Rates, Favero R. Paula, Daiana Silva Ávila +9 morewiley +1 more sourceARIA‐EAACI 2025: Person‐Centred, Digitally Enabled and Artificial Intelligence‐Assisted Change Management in Airway Diseases
Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.ABSTRACT
Allergic Rhinitis and its Impact on Asthma (ARIA) was, up until 2017, a guideline using the best evidence (Grading of Recommendations, Assessment, Development and Evaluation, GRADE) and developed as a change management strategy. A second change management strategy—in collaboration with the European Academy of Allergy and Clinical Immunology ...Jean Bousquet, Bernardo Sousa‐Pinto, Mohamed H. Shamji, Maria J. Torres, Ludger Klimek, Holger J. Schünemann, Mario Morais‐Almeida, Rafael José Vieira, Alkis Togias, Boleslaw Samolinski, Arunas Valiulis, Siân Williams, Oliver Pfaar, Torsten Zuberbier, Anna Bedbrook, Wienczyslawa Czarlewski, Maryam Ali Al‐Nesf, Rita Amaral, Josep M. Anto, Antonio Bognanni, Luisa Brussino, Alvaro A. Cruz, Violeta Kvedariene, Habib Douagui, Nikolaos G. Papadopoulos, G. Walter Canonica, Ivan Cherrez‐Ojeda, Mark Dykewicz, Bilun Gemicioglu, Mattia Giovannini, Brigita Gradauskiene, Tari Haahtela, Cristina Jacomelli, Tuomas Jartti, Miloš Jeseňák, Piotr Kuna, Désirée E. Larenas‐Linnemann, Amir H. A. Latiff, Bryan Martin, Yousser Mohammad, Kari Nadeau, Elizabete Nunes, Ken Ohta, Martial Ouédraogo, Padukudru A. Mahesh, Isabella Pali‐Schölll, Ana Margarida Pereira, Frederico S. Regateiro, Nicolas Roche, Mikhail Sofiev, Luis Taborda‐Barata, Charlotte Suppli Ulrik, Sanna K. Toppila‐Salmi, Marylin Valentin Rostan, Leticia de las Vecillas, Maria Teresa Ventura, Giovanni Viegi, De Yun Wang, He Zhang, Luo Zhang, Giorgio Ciprandi, Juan Carlos Ivancevich, Nikolai Khaltaev, Olga Lourenço, Lucas Leemann, Marine Savouré, Juan Jose Yepes‐Nuñez, Arzu Yorgancioglu, Baharudin Abdullah, Mona Al‐Ahmad, Julijana Asllani, Karl‐C. Bergmann, Jonathan A. Bernstein, Michael S. Blaiss, Fulvio Braido, Pedro Carreiro‐Martins, Lorenzo Cecchi, Antonio F. M. Giuliano, George Christoff, Ieva Cirule, Jaime Correia‐de‐Sousa, Elisio M. Costa, Biljana Cvetkovski, Stefano Del Giacco, Philippe Devillier, Dejan Dokic, Maia Gotua, Maria Antonieta Guzman, Elham Hossny, Tomohisa Iinuma, Carla Irani, Zhanat Ispayeva, Kaja Julge, Igor Kaidashev, Kazi S. Bennoor, Helga Kraxner, Inger Kull, Marek Kulus, Maciej Kupczyk, Andriy Kurchenko, Xin Luo, Stefania La Grutta, Lan Le Thi Tuyet, Michael Makris, Branislava Milenkovic, Neven Miculinic, Sang Min Lee, Stephen Montefort, André Moreira, Joaquim Mullol, Rachel Nadif, Alla Nakonechna, Hugo E. Neffen, Stefania Nicola, Marek Niedoszytko, Dieudonné Nyembue, Robyn E. O’Hehir, Ismail Ogulur, Yoshitaka Okamoto, Markus Ollert, Heidi Olze, Oscar Palomares, Petr Panzner, Hae‐Sim Park, Vincenzo Patella, Ruby Pawankar, Constantinos Pitsios, Todor A. Popov, Francesca Puggioni, Santiago Quirce, Agné Ramonaité, Marysia Recto, Maria Susana Repka‐Ramirez, Karla Robles‐Velasco, Menachem Rottem, Marianella Salapatas, Joaquin Sastre, Nicola Scichilone, Juan‐Carlos Sisul, Dirceu Solé, Manuel Soto‐Martinez, Milan Sova, Katarina Stevanovic, Pongsakorn Tantilipikorn, Ana Todo‐Bom, Vladyslav Tsaryk, Ioanna Tsiligianni, Marilyn Urrutia‐Pereira, Erkka Valovirta, Tuula Vasankari, Dana Wallace, Margitta Worm, Osman M. Yusuf, Fares Zaitoun, Mihaela Zidarn, on behalf of ARIA study group +155 morewiley +1 more sourceDesign, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents
Drug Development Research, Volume 87, Issue 5, August 2026.ABSTRACT
A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci +10 morewiley +1 more sourceDiscovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity
Drug Development Research, Volume 87, Issue 5, August 2026.ABSTRACT
A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN +11 morewiley +1 more sourceAnalysis of Climate Variability of Homogeneous Regions of Rainfall Anomalies in Southeast South America (SESA)
International Journal of Climatology, Volume 46, Issue 10, August 2026.We studied rainfall variability and cyclicity in six Homogeneous Regions of Rainfall Anomalies (HRRA) in Southeast South America (SESA) from 1961 to 2020 to understand the occurrence of droughts and above‐average rainfall. We use a continental analysis scale, focusing on seasonal, interannual, and interdecadal cycles, and their association with modes ...Tainã Costa Peres, Francisco Eliseu Aquino, Denilson Ribeiro Viana, Éder Leandro Bayer Maier, Pedro Teixeira Valente +4 morewiley +1 more sourceDNA barcoding for identification of species involved in wildlife strikes at Brazilian airports
The Journal of Wildlife Management, Volume 90, Issue 6, August 2026.A collaborative network of 42 Brazilian airports applied DNA barcoding to identify 80 species involved in wildlife strikes. Among them, 32 species (17 birds and 15 bats) were not currently available in Brazil's wildlife strike reporting database, underscoring the value of molecular tools for strengthening wildlife strike monitoring. Abstract
This study Andre Akira Gonzaga Yoshikawa, Bernardo Perin Cima, Iara Carolini Pinheiro, Isabelle Louise Pimenta‐Blight, Fernando Seabra, Carmen Elena Barragán‐Ruiz, Dalmo Almeida de Azevedo, Mariana Pires de Campos Telles, Raquel Nascimento Rocha, Karla Andréa Rodrigues dos Santos, Wellington Longuini Repette, José Pedro Francisconi Junior +11 morewiley +1 more sourceUptake and Transport of Monotropein and Monotropein Esters in a Caco‐2/HT29‐MTX‐E12 Co‐Culture Model
Molecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.Monotropein and its naturally occurring ester derivatives (monotropein‐10‐coumarate and monotropein‐10‐cinnamate) from Gaultheria spp. berries exhibit limited intestinal permeability in a validated Caco‐2:HT29‐MTX‐E12 co‐culture model. Absorption occurs predominantly via passive diffusion, with partial SGLT1‐ and OATP‐mediated uptake contribution for ...Christian Zielinski, Victor Schmalle, Luise A. Lauer, Tim Hammerschick, Felix Rüttler, Walter Vetter, Jan Frank, Felipe Jiménez‐Aspee +7 morewiley +1 more source