Results 231 to 240 of about 3,942,953 (265)

Pan-cancer analysis identifies JMJD6 as an oncogene and prognostic biomarker. [PDF]

Discov Oncol
Liu L, Li T, He J, Liu G.
europepmc   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

C17orf75 (Njmu-R1) promotes hepatocellular carcinoma progression: a pan-cancer analysis and experimental validation. [PDF]

Front Immunol
Liang H, Liu N, Zhai YM, Guo S, Du K, Li K, Zhu X.   +6 more
europepmc   +1 more source

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

Pan-Cancer Quantification of Driver Alteration Transmission Across Molecular Layers Reveals Limited Propagation to Protein Abundance. [PDF]

Int J Cancer
Nakano H.
europepmc   +1 more source

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

Advanced Science, EarlyView.
PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan, Hong‐feng Zheng, Mu‐chen Li, Jia‐lin Zhou, Hang‐biao Zhang, Dong‐hao Lyu, Yi‐fan Tang, Tian‐yue Yang, Yi‐fan Liu, Zi‐chang Liu, Wen‐jie Ma, Yuan‐bo Zong, Jian‐gui Liu, Zi‐xuan Gong, Hao Zhang, Ke‐qin Dong, Wang Zhou, Jian‐qin Ye, Xin‐gang Cui   +18 more
wiley   +1 more source

Cofilin1-driven cytoskeletal remodeling modulates pan-cancer CD8⁺ T cell immunotherapy responses. [PDF]

Cell Rep Med
Li L, Chao Z, Li J, Ma C, Zhang R, Zhang J, Luo J, Horne D, Wang Y, Hao X, Zhang C, Guo X, Ma S, Peng H, Hu Z, Yuh B, Wei GH, Yang X, Zhang Q, Wang B, Zhang X, Liu Z, Zhang Z, Lan P, Wang Z.   +24 more
europepmc   +1 more source

<i>CDKN2AIPNL</i>: a potential pan-cancer biomarker. [PDF]

Front Genet
Yuan Y, Ma SX, Liu H, Gong Y, Sun X, Wang Q, Zhang W.   +6 more
europepmc   +1 more source

ICIsAtlas reveals a suppressive NK cell niche in pan-cancer immunotherapy profiles. [PDF]

Commun Biol
Xie Y, Lin J, Liu H, Xiong Y, Han J, Huang Z, Weng J, Wan Z, Li P, Wang P, Liu X, Wu L, Cai Q, Huang M, Luo Y, Wang X, Yu H.   +16 more
europepmc   +1 more source

Pan-cancer investigation identifies ARL4A as a prospective therapeutic indicator for thyroid cancer. [PDF]

Discov Oncol
Men Y, Zhao J, Feng R, Wang Z, Ye B, Zheng Y, Yang Z, Chen X, Zhang L, Wang N, Chen Y, Shao Y, Wang H, Song Y, Ding C.   +14 more
europepmc   +1 more source