PLoS Biology, 2008 Both endocrine and exocrine pancreatic cells arise from pancreatic-duodenal homeobox 1 (pdx1)-positive progenitors. The molecular mechanisms controlling cell fate determination and subsequent proliferation, however, are poorly understood.
Zhi Jiang +8 more
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The Role of Bile in the Regulation of Exocrine Pancreatic Secretion [PDF]
, 1992 As early as 1926 Mellanby (1) was able to show that introduction of bile into the duodenum of anesthetized cats produces a copious flow of pancreatic juice.
Riepl, Rudolf L., Lehnert, Peter
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Dorsal Pancreatic Agenesis Associated With New-Onset Diabetes Mellitus and Acute Pancreatitis in an 18-Year-Old Man: A Case Report. [PDF]
Clin Case RepABSTRACT Dorsal pancreatic agenesis (DPA) is a rare congenital disorder resulting from failure of development of the dorsal pancreatic bud. Complete DPA implies absence of the pancreatic neck, body, and tail and can be associated with both diabetes mellitus and pancreatitis. The patient was an 18‐year‐old man admitted with a history of epigastric pain,
Rab M +5 more
europepmc +2 more sources
Pancreas—Its Functions, Disorders, and Physiological Impact on the Mammals’ Organism
Frontiers in Physiology, 2022 This review aimed to analyze the scientific literature on pancreatic diseases (especially exocrine pancreatic insufficiency). This review also describes the correlation between the physiological fitness of the pancreas and obesity.
Monika Karpińska, Marian Czauderna
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Aetiology-Specific Pancreatic Enzyme Dose Requirements and Treatment Outcomes in Pancreatic Exocrine Insufficiency: The Multicentre EURO-PEI Registry. [PDF]
United European Gastroenterol JABSTRACT Background Pancreatic exocrine insufficiency (PEI) is a maldigestion syndrome leading to symptoms and nutritional deficiencies. Prospective real‐world data on pancreatic enzyme replacement therapy (PERT) dose requirements across aetiologies are limited. Objective To define PERT dose requirements and treatment outcomes across PEI aetiologies in
Domínguez-Muñoz JE +17 more
europepmc +2 more sources
Proglucagon-derived peptides do not significantly affect acute exocrine pancreas in rat [PDF]
, 2015 Objectives: Reports have suggested a link between treatment with glucagon-like peptide 1 (GLP-1) analogues and an increased risk of pancreatitis. Oxyntomodulin, a dual agonist of both GLP-1 and glucagon receptors, is currently being investigated as a ...
Akalestou, E +5 more
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Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man [PDF]
, 1994 Intraduodenal (i.d.) application of bile or Na-taurodeoxycholate (TDC) dose dependently enhances basal exocrine pancreatic secretion. The hydrokinetic effect is mediated at least in part by secretin.
Teufel, Johannes +3 more
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Journal of Tissue Engineering, 2017 Despite progress in the field of decellularization and recellularization, the outcome for pancreas has not been adequate. This might be due to the challenging dual nature of pancreas with both endocrine and exocrine tissues.
Erik Elebring +3 more
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Oxidative damage and exocrine dysfunction of ovine fetal pancreas are induced by maternal nutritional restriction [PDF]
Revista Brasileira de Zootecnia, 2023 This study investigated oxidative damage and exocrine dysfunction of fetal pancreas caused by maternal nutritional restriction. Eighteen ewes carrying singleton fetus were randomly divided into control group (CG, ad libitum, 0.67 MJ ME/BW0.75/d, n = 6 ...
Yang Zi +5 more
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RELATIVE EXOCRINE INSUFFICIENCY OF PANCREAS IN CHILDREN
Вопросы современной педиатрии, 2012 Diseases of gastro-intestinal tract are often accompanied by relative insufficiency of pancreas exocrine function, which can be asymptomatic, but demands including enzymes in complex treatment.
A. I. Khavkin
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