Results 51 to 60 of about 135,933 (247)

Refining a preclinical model of viral myocarditis in accordance with biotech standards

Animal Models and Experimental Medicine, EarlyView.
This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H. Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E. Camacho Londoño   +9 more
wiley   +1 more source

Fecal elastase-1 and ultrasonography for assessment of exocrine pancreatic function in children with cystic fibrosis [PDF]

Zagazig University Medical Journal
Background: Cystic fibrosis (CF) is an autosomal recessive disorder affecting the exocrine functions of many organs including the pancreas. Clinical and laboratory recognition of pancreatic insufficiency is important for proper treatment.
Khalid Salah, Aya Abd-Allah, Sameh Hegab, Hanan Sameer, Dina Sarhan   +4 more
doaj   +1 more source

Impact of the pancreatic enzyme replacement therapy (PERT) shortage on prescribing in England: Analysis of national data

British Journal of Clinical Pharmacology, EarlyView.
Aim Pancreatic enzyme replacement therapy (PERT) is essential for the management of pancreatic exocrine insufficiency. Since June 2023, the United Kingdom has been affected by a global shortage of PERT. We investigated the impact of this shortage on national prescribing trends for Creon, Nutrizym, Pancrex and Pangrol.
Teena S. Varghese, Mary E. Phillips, Louis Fisher, Helen Fitt, Adam Frampton, Christopher Wood, Agnieszka Lemanska   +6 more
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases:Workshop Proceedings [PDF]

, 2022
The Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested ...
Bernal-Mizrachi, Ernesto, Whitcomb, David C., Caicedo, Alejandro, Hara, Manami, Pandol, Stephen J., Ouaamari, Abdelfattah El, Artandi, Steven, Yadav, Dhiraj, Amundadottir, Laufey T, Mastracci, Teresa L., Hull-Meichle, Rebecca L., Campbell-Thompson, Martha, Phelps, Edward A., El Ouaamari, Abdelfattah, Olesen, Søren S., Goodarzi, Mark O., Muzumdar, Mandar D, Olesen, Søren S, Olesen, Søren S.; id_orcid, Hull-Meichle, Rebecca L, Naren, Anjaparavanda P, Bellin, Melena D, Powers, Alvin C., Whitcomb, David C, Oakes, Scott A, Stabler, Cherie L, Zaghloul, Norann A., Mastracci, Teresa L, Klein, Alison P, Bellin, Melena D., Kopp, Janel L, Cruz-Monserrate, Zobeida, Geisz, Andrea, Amundadottir, Laufey T., Phelps, Edward A, Zaghloul, Norann A, Alvarsson, Alexandra, Goodarzi, Mark O, Powers, Alvin C, Klein, Alison P., Kopp, Janel L., Naren, Anjaparavanda P., Oakes, Scott A., Yong, Jing, Kulkarni, Rohit N., Kleger, Alexander, Muzumdar, Mandar D., Apte, Minoti, Gaulton, Kyle J, Gaulton, Kyle J., Kulkarni, Rohit N, Pandol, Stephen J, Stabler, Cherie L., Olesen, Soren S., Sander, Maike, Tirkes, Temel   +55 more
core   +1 more source

PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice

BMC Cell Biology, 2007
Background Deficiency of the PERK eIF2α kinase in humans and mice results in postnatal exocrine pancreatic atrophy as well as severe growth and metabolic anomalies in other organs and tissues.
Iida Kaori, Li Yulin, McGrath Barbara C, Frank Ami, Cavener Douglas R   +4 more
doaj   +1 more source

Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes. [PDF]

PLoS ONE, 2015
Type 1 diabetes (T1D) and type 2 diabetes (T2D) are associated with functional beta cell loss due to ongoing inflammation. Despite shared similarities, T1D is an autoimmune disease with evidence of autoantibody production, as well as a role for exocrine ...
Tanya C Burch, Margaret A Morris, Martha Campbell-Thompson, Alberto Pugliese, Jerry L Nadler, Julius O Nyalwidhe   +5 more
doaj   +1 more source

Histological Study of Exocrine Portion of Pancreas in Guinea fowl (Numida meleagris)

Wasit Journal for Pure Sciences, 2023
 The histological structure of the exocrine pancreas was examined in the current study for fifteen healthy adult female Laying hens. The study showed the pancreas was serous tubuloacinar gland, which has both an exocrine and an endocrine component, the ...
Rawaa Taha Mahdi, Ali Fayadh Bargooth
doaj   +1 more source

Engineered molecular diagnostic strategies for hepatocellular carcinoma: Integrating flexible photonic barcodes, liquid biopsies, and AI‐enhanced sensing platforms

FlexMat, EarlyView.
Abstract Early diagnosis of hepatocellular carcinoma (HCC) remains challenging because conventional serum biomarkers, especially alpha‐fetoprotein (AFP), show limited sensitivity for early‐stage disease. Recent progress in engineered molecular diagnostics provides new opportunities to improve HCC detection through integrated material, molecular, and ...
Jingzhi Xue, Wanqi Yang, Xiaoyu Liu, Xuehui Chu, Wei Li, Jinglin Wang   +5 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source